Results 41 to 50 of about 3,116,502 (374)

From Proteinuria to Fibrosis: An Update on Pathophysiology and Treatment Options

open access: yesKidney & Blood Pressure Research, 2021
Background: Proteinuria is a key biomarker in nephrology. It is central to diagnosis and risk assessment and the primary target of many important therapies.
Sonia Sharma, Brendan Smyth
doaj   +1 more source

Intravital Imaging with Two-Photon Microscopy: A Look into the Kidney

open access: yesPhotonics, 2022
Fluorescence microscopy has represented a crucial technique to explore the cellular and molecular mechanisms in the field of biomedicine. However, the conventional one-photon microscopy exhibits many limitations when living samples are imaged.
Vincenzo Costanzo, Michele Costanzo
doaj   +1 more source

Hypertension in the elderly. Which are the blood pressure threshold values? [PDF]

open access: yes, 2019
Managing blood pressure is often difficult in the elderly, not only because of comorbidities, but also due to vascular remodelling and the changes in the renal and endocrine physiology.
Battistoni, Allegra   +3 more
core   +1 more source

Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury

open access: yesNature Communications, 2020
Acute kidney injury is a major health problem amongst hospitalized patients. Here the authors provide a comprehensive characterization of enhancer and super-enhancer elements, and the transcription factor motifs associated with these elements in response
Julia Wilflingseder   +9 more
doaj   +1 more source

Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system [PDF]

open access: yes, 2014
The physiological hydroelectrolytic balance and the redox steady state in the kidney are accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors.
Choi, Marcelo Roberto   +6 more
core   +3 more sources

Sympathetic nerve-derived ATP regulates renal medullary vasa recta diameter via pericyte cells: a role for regulating medullary blood flow? [PDF]

open access: yes, 2013
Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins.
Crawford, C.   +4 more
core   +2 more sources

Renal Physiology in Pregnancy [PDF]

open access: yesObstetrical & Gynecological Survey, 1979
Summary The changes which occur in renal excretory function during pregnancy are discussed. The relationship between glomerular filtration rate and effective renal plasma flow is examined in the light of new serial data obtained under conditions of saline diuresis.
openaire   +3 more sources

Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-δ/p38 MAPK pathway activation and trough increased Na+/H+ exchanger isoform 1 activity

open access: yesBMC Nephrology, 2018
Background Angiotensin II (Ang II) contributes to the progression of renal diseases associated with proteinuria and glomerulosclerosis mainly by inducing podocyte apoptosis.
Vanessa Gerolde Cardoso   +8 more
doaj   +1 more source

High salt induced augmentation of angiotensin II mediated hypertension is associated with differential expression of tumor necrosis factor-alpha receptors in the kidney

open access: yesExploration of Medicine, 2022
Aim: Chronic high salt (HS) intake causes minimal changes in blood pressure (BP) but it induces augmented hypertensive response to angiotensin II (AngII) administration in rodents. The mechanism of this augmentation is not clearly understood.
Dewan S. A. Majid   +3 more
doaj   +1 more source

High‐salt intake reduces renal tissue levels of inflammatory cytokines in mice

open access: yesPhysiological Reports, 2021
High salt (HS) intake is usually considered as an aggravating factor to induce inflammatory renal injury. However, the changes in the renal levels of inflammatory cytokines during HS intake is not yet clearly defined.
Purnima Singh   +3 more
doaj   +1 more source

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