Results 51 to 60 of about 3,239,906 (356)

Sphingosine 1-phosphate in renal diseases [PDF]

, 2013
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Huwiler, Andrea, Koch, Alexander, Pfeilschifter, Josef Martin   +2 more
core   +2 more sources

From Proteinuria to Fibrosis: An Update on Pathophysiology and Treatment Options

Kidney & Blood Pressure Research, 2021
Background: Proteinuria is a key biomarker in nephrology. It is central to diagnosis and risk assessment and the primary target of many important therapies.
Sonia Sharma, Brendan Smyth
doaj   +1 more source

High salt induced augmentation of angiotensin II mediated hypertension is associated with differential expression of tumor necrosis factor-alpha receptors in the kidney

Exploration of Medicine, 2022
Aim: Chronic high salt (HS) intake causes minimal changes in blood pressure (BP) but it induces augmented hypertensive response to angiotensin II (AngII) administration in rodents. The mechanism of this augmentation is not clearly understood.
Dewan S. A. Majid, Alexander Castillo, Minolfa C. Prieto, L. Gabriel Navar   +3 more
doaj   +1 more source

Alterations of haemodynamic parameters in spontaneously hypertensive rats by Aristolochia ringens Vahl. (Aristolochiaceae)

Journal of Traditional and Complementary Medicine, 2018
Aristolochia ringens Vahl. (Aristolochiaceae (AR); 馬兜鈴 mǎ dōu líng) is used traditionally in Nigeria for the management of various disorders including oedema. Preliminary investigation revealed its modulatory effect on the cardiovascular system.
Flora Ruth Aigbe, Abdul Sattar Zubaid Munavvar, Hassan Rathore, Olorunfemi Eseyin, Yen Pei Pei, Safia Akhtar, Ashfaq Chohan, Hui Jin, Jooli Khoo, Samual Tan, Mohammed Lazhari, Sheryar Afzar, Fiaz Ahmed, Olufunmilayo Olaide Adeyemi, Edward Johns   +14 more
doaj   +1 more source

Renal pericytes: regulators of medullary blood flow [PDF]

, 2012
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Agmon Y., Beach R.E., Biondi M., Burnstock G., Casellas D., Cohen H.J., Edwards R.M., Guan Z., Harrison‐Bernard L.M., Harrison‐Bernard L.M., Jamison R.L., Kreisberg M.S., Kriz W., Larson T.S., Lazarowski E.R., Lerman L.O., Majid D.S., Pallone T.L., Rouget C., Seldin D.W., Stern M.D., Strick D.M., Takenaka T., Takezawa K., Turner M.R., Unwin R.J., Yamagishi S., Yang S.   +27 more
core   +1 more source

Multiparametric assessment of renal physiology in healthy volunteers using noninvasive magnetic resonance imaging.

AJP - Renal Physiology, 2019
Noninvasive methods of magnetic resonance imaging (MRI) can quantify parameters of kidney function. The main purpose of this study was to determine baseline values of such parameters in healthy volunteers.
Per Eckerbom, P. Hansell, E. Cox, Charlotte E Buchanan, J. Weis, F. Palm, S. Francis, P. Liss   +7 more
semanticscholar   +1 more source

The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]

, 2013
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E, Craigie, Eilidh, Unwin, Robert J, Wildman, Scott S.P.   +3 more
core   +3 more sources

Chymase Dependent Pathway of Angiotensin II Generation and Rapeseed Derived Peptides for Antihypertensive Treatment of Spontaneously Hypertensive Rats

Frontiers in Pharmacology, 2021
The contribution of chymase, one of the enzymes responsible for angiotensin II generation in non-ACE pathway, remains unclear in the development of hypertension.
Iwona Baranowska, Olga Gawrys, Malwina M. Roszkowska-Chojecka, Bozena Badzynska, Dagmara Tymecka, Krzysztof H. Olszynski, Elzbieta Kompanowska-Jezierska   +6 more
doaj   +1 more source

Functional expression of TRPV4 channels in human collecting duct cells: implications for secondary hypertension in diabetic nephropathy [PDF]

, 2012
Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress.
Bland, Rosemary, Hills, Claire E., Squires, Paul E.   +2 more
core   +3 more sources

HDAC9 is an epigenetic repressor of kidney angiotensinogen establishing a sex difference

Biology of Sex Differences, 2017
Background Sexual difference has been shown in the pathogenesis of chronic kidney disease induced by hypertension. Females are protected from hypertension and related end-organ damage.
Camille T. Bourgeois, Ryousuke Satou, Minolfa C. Prieto   +2 more
doaj   +1 more source