Results 61 to 70 of about 3,116,502 (374)
Scientific Reports, 2023 Focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome, which is characterized by podocyte injury. Given that the pathophysiology of nondiabetic glomerulosclerosis is poorly understood and targeted therapies to prevent ...
Guilherme Lopes-Gonçalves +10 more
doaj +1 more source
Why hydroxyethyl starch solutions should NOT be banned from the operating room [PDF]
, 2014 This review summarises the new insights into the physiology of perioperative fluid therapy and analyses recent studies of the safety of the use of HES solutions in the fluid management of critically ill patients.
De Baerdemaeker, Luc, De Hert, Stefan
core +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Abnormal renal hemodynamic responses to salt‐loading are thought to contribute to salt‐sensitive (SS) hypertension. However, this is based largely on studies in anesthetized animals, and little data are available in conscious SS and salt ...
Jacqueline C. Potter +10 more
doaj +1 more source
Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells [PDF]
, 2009 When the succinate receptor (SUCNR1) is activated in the afferent arterioles of the glomerulus it increases renin release and induces hypertension.
Deen +37 more
core +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Frontiers in PhysiologyIntroductionAcute kidney injury (AKI) is a clinical syndrome characterized by rapid decline in renal function with varying severity. In this context, tubular function is impaired in ischemia-induced AKI. Although there are no effective therapies for AKI,
Guilherme Lopes-Gonçalves +4 more
doaj +1 more source
Molecular bases of circadian rhythmicity in renal physiology and pathology [PDF]
, 2017 The physiological processes that maintain body homeostasis oscillate during the day. Diurnal changes characterize kidney functions, comprising regulation of hydro-electrolytic and acid-base balance, reabsorption of small solutes and hormone production ...
Bonny, Olivier +3 more
core
The role of pendrin in renal physiology.
Annual Review of Physiology, 2015 Pendrin is a Na(+)-independent Cl(-)/HCO3(-) exchanger that localizes to type B and non-A, non-B intercalated cells, which are expressed within the aldosterone-sensitive region of the nephron, i.e., the distal convoluted tubule, the connecting tubule ...
S. Wall, Yoskaly Lazo-Fernandez
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Effect of fasting on renal physiology [PDF]
Journal of Fasting and Health, 2014 Total abstention from food and water from sunrise to sunset during the month of Ramadan, is practiced by hundreds of millions of Muslims throughout the world.
Achraf Hendawy
doaj +1 more source