Results 61 to 70 of about 3,239,906 (356)

Neutrophil gelatinase-associated lipocalin: its response to hypoxia and association with acute mountain sickness. [PDF]

, 2013
Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility.
Begley, J, Boos, C, Hooper, T, King, R, Mellor, A, O'Hara, J, Piper, R, Smith, C, Stacey, M, Turner, S, Woods, DR, Yarker, J   +11 more
core   +2 more sources

Paricalcitol prevents MAPK pathway activation and inflammation in adriamycin-induced kidney injury in rats [PDF]

Journal of Pathology and Translational Medicine
Background Activation of the mitogen-activated protein kinase (MAPK) pathway induces uncontrolled cell proliferation in response to inflammatory stimuli.
Amanda Lima Deluque, Lucas Ferreira de Almeida, Beatriz Magalhães Oliveira, Cláudia Silva Souza, Ana Lívia Dias Maciel, Heloísa Della Coletta Francescato, Cleonice Giovanini, Roberto Silva Costa, Terezila Machado Coimbra   +8 more
doaj   +1 more source

Evaluation of glomerular sirtuin-1 and claudin-1 in the pathophysiology of nondiabetic focal segmental glomerulosclerosis

Scientific Reports, 2023
Focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome, which is characterized by podocyte injury. Given that the pathophysiology of nondiabetic glomerulosclerosis is poorly understood and targeted therapies to prevent ...
Guilherme Lopes-Gonçalves, Juliana Martins Costa-Pessoa, Ruan Pimenta, Ana Flavia Tostes, Eloisa Martins da Silva, Felipe Lourenço Ledesma, Denise Maria Avancini Costa Malheiros, Roberto Zatz, Karina Thieme, Niels Olsen Saraiva Câmara, Maria Oliveira-Souza   +10 more
doaj   +1 more source

Renal phosphate handling: Physiology

Indian Journal of Endocrinology and Metabolism, 2013
Phosphorus is a common anion. It plays an important role in energy generation. Renal phosphate handling is regulated by three organs parathyroid, kidney and bone through feedback loops.
Narayan Prasad, Dharmendra Bhadauria
doaj   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

Developing a model renal corpuscle to illustrate concepts in renal physiology

Advances in Physiology Education
Models that illustrate renal fluid dynamics are scarce within the secondary and postsecondary landscape. This work summarizes the efforts to build a rudimentary model renal corpuscle (MRC) that can be employed in a problem-based learning exercise or ...
Jacob E. Hansen, Jonathan A. Chickering, Amy J. Sullivan, Zachary E. Stelter   +3 more
doaj   +1 more source

Hypoxia/Reoxygenation of Rat Renal Arteries Impairs Vasorelaxation via Modulation of Endothelium-Independent sGC/cGMP/PKG Signaling

Frontiers in Physiology, 2018
Ischemia/reperfusion injury holds a key position in many pathological conditions such as acute kidney injury and in the transition to chronic stages of renal damage.
Diana Braun, Diana Braun, Christa Zollbrecht, Stefanie Dietze, Stefanie Dietze, Rudolf Schubert, Stefan Golz, Holger Summer, Pontus B. Persson, Pontus B. Persson, Mattias Carlström, Marion Ludwig, Marion Ludwig, Andreas Patzak, Andreas Patzak   +14 more
doaj   +1 more source

Uncoupling protein 2: a key player and a potential therapeutic target in vascular diseases [PDF]

, 2017
Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative ...
Forte, Maurizio, Migliarino, Serena, Perelli, Marika, Pierelli, Giorgia, Rubattu, Speranza, Stanzione, Rosita, Volpe, Massimo   +6 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Insights into the effects of apelin-13 on renal function and NHE3 activity following ischemia/reperfusion-induced acute kidney injury

Frontiers in Physiology
IntroductionAcute kidney injury (AKI) is a clinical syndrome characterized by rapid decline in renal function with varying severity. In this context, tubular function is impaired in ischemia-induced AKI. Although there are no effective therapies for AKI,
Guilherme Lopes-Gonçalves, Juliana Martins Costa-Pessoa, Mariana Charleaux de Ponte, Heitor Macedo Braz, Maria Oliveira-Souza   +4 more
doaj   +1 more source