Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Afferent arteriole responsiveness to endothelin receptor activation: does sex matter?
Biology of Sex Differences, 2019 Background The pathogenesis of hypertension is distinct between men and women. Endothelin-1 (ET-1) is a potential contributor to sex differences in the pathophysiology of hypertension.
Eman Y. Gohar +3 more
doaj +1 more source
Prognostic robustness of serum creatinine based AKI definitions in patients with sepsis: a prospective cohort study [PDF]
, 2015 Background: It is unclear how modifications in the way to calculate serum creatinine (sCr) increase and in the cut-off value applied, influences the prognostic value of Acute Kidney Injury (AKI).
Dhondt, Annemieke +4 more
core +2 more sources
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Comparação do perfil dos pacientes que internaram na UTI do HU/UFSC e foram a óbito com o daqueles que receberam alta hospitalar. [PDF]
, 2005 Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Cardoso, Hugo Alfredo Koerich Vieira
core
The essential roles of metal ions in insect homeostasis and physiology [PDF]
, 2017 Metal ions play distinct roles in living organisms, including insects. Some, like sodium and potassium, are central players in osmoregulation and ‘blood and guts’ transport physiology, and have been implicated in cold adaptation.
Dow, Julian A.T.
core +1 more source
Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease [PDF]
, 2016 The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD.
Heerspink, Hiddo J.L. +2 more
core +5 more sources
Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2
Diabetologia, 2018 The concentration of glucose in plasma is held within narrow limits (4–10 mmol/l), primarily to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by ensuring that glucose is not lost in the urine.
C. Ghezzi, D. Loo, E. M. Wright
semanticscholar +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source