Results 161 to 170 of about 538,702 (314)

Multidisciplinary guidelines on renal replacement therapy in intensive care medicine. [PDF]

Crit Care
Meersch-Dini M, Abu-Tair M, Bayer M, Brinkmann A, Bellmann R, Brunkhorst F, Custodis F, Czock D, Frey O, Galle J, Hermes C, Joannidis M, John S, Jörres A, Kerz T, Kindgen-Milles D, Koczor M, Kram R, Kuhlmann M, Oppert M, Schlieper G, Schmitz M, Zarbock A, Willam C.   +23 more
europepmc   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Effects of extracorporeal membrane oxygenation and/or renal replacement therapy on piperacillin/tazobactam levels in critically ill patients. [PDF]

Front Pharmacol
Riese T, Lauter S, Surat G, Kurlbaum M, Roeder D, Meybohm P, Hoppe K.   +6 more
europepmc   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

WCN24-772 COMPARATIVE ANALYSIS OF THE COVID-19 COURSE IN THE KIDNEY TRANSPLANT RECIPIENTS DURING DIFFERENT EPIDEMIOLOGICAL PERIODS

Kidney International Reports
Kirill Komissarov, Aleh Kalachyk, Vadzim Matsiushko, Zoya Bohush, Tamara Amvrosieva   +4 more
doaj   +1 more source

Evaluation of continuous renal replacement therapy efficacy in severe caffeine intoxication: concentration-dependent variation in caffeine clearance. [PDF]

CEN Case Rep
Takeda S, Chiba H, Yamazaki T, Tsukada Y, Onodera M, Iseki K, Harada K.   +6 more
europepmc   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Outcomes of Dialysis Modality Switch: A Matched Cohort Analysis from a National Renal Replacement Therapy Registry, 2010-2022. [PDF]

J Clin Med
Namimi-Halevi C, Kunin M, Bromberg M, Dichtiar R, Beckerman P.   +4 more
europepmc   +1 more source

Renal replacement therapy: a practical update

Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 2019
G. Alvarez, C. Chrusch, Terry Hulme, Juan G Posadas-Calleja   +3 more
semanticscholar   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source