Results 61 to 70 of about 10,740 (300)

Response to Renal Resistive Index and Cardiovascular and Renal Outcomes in Essential Hypertension [PDF]

Hypertension, 2013
We thank Dr Heine et al1 for their interest in our recent findings2,3 and for their crucial and constructive criticisms and comments concerning the renal resistive index (RI). In response, we classified the primary composite end points into cardiovascular events, including nonfatal congestive heart failure, stroke, myocardial infarction, aortic ...
Yohei, Doi, Yoshio, Iwashima, Fumiki, Yoshihara, Kei, Kamide, Shin-ichiro, Hayashi, Yoshinori, Kubota, Satoko, Nakamura, Takeshi, Horio, Yuhei, Kawano   +8 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Comparison of renal arterial resistive index in type 2 diabetic nephropathy stage 0-4

European Journal of Translational Myology, 2019
Chronic kidney disease (CKD) is one of world health problems and its prevalence and incidence is increasing. Chronic Kidney Failure involves a range of pathophysiologic processes that are associated with impaired renal function, leading to cardiovascular
Sharareh Sanei Sistani, Ali Alidadi, Alireza Ansari Moghadam, Fatemeh Mohamadnezhad, Bahareh Heshmat Ghahderijani   +4 more
doaj   +1 more source

INVERSE RELATIONSHIP BETWEEN AORTIC ROOT DIAMETER AND RENAL FUNCTION IN HYPERTENSIVE SUBJECTS [PDF]

, 2015
Recent studies suggest that enlarged aortic root diameter (ARD) may predict cardiovascular events in absence of aneurysmatic alterations. Little is known about the influence of renal function on ARD.
Cerasola, G., COTTONE, Santina, D'Amico, S., Geraci, G., MORREALE, Massimiliano, MULE', Giuseppe, Nardi, C., NARDI, Emilio   +7 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

PERUBAHAN RESISTIVE INDEX DOPPLER ULTRASONOGRAFI PADA PENDERITA GAGAL GINJAL KRONIS [PDF]

, 2013
Peningkatan usia harapan hidup masyarakat seiring dengan kemajuan di berbagai bidang, tidak terkecuali pada pelayanan kesehatan, terjadilah perubahan-perubahan pada pola penyakit.
Suyono,
core  

Digital detection of exosomes by interferometric imaging [PDF]

, 2016
Exosomes, which are membranous nanovesicles, are actively released by cells and have been attributed to roles in cell-cell communication, cancer metastasis, and early disease diagnostics.
Benussi, Luisa, Bettotti, Paolo, Chiari, Marcella, Ciani, Miriam, Cretich, Marina, Daaboul, George G., Freedman, David S., Gagni, Paola, Ghidoni, Roberta, Ozkumur, Ayca Yalcin, Piotto, Chiara, Prosperi, Davide, Santini, Benedetta, Unlu, M. Selim   +13 more
core   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Correlation of Albuminuria and Renal Doppler Indices with Myocardial Function in Patients with Nephrotic Syndrome

SVU - International Journal of Medical Sciences
Background: Nephrotic syndrome (NS) is characterized by proteinuria and edema, often stemming from minimal change disease. Secondary causes include systemic conditions and medications.
AbdelKader A. Hashim, Ghada M. Abdelrazek , ِAreej Alkhateeb, Aml Ahmed Shohdy , Ahmed G. Bakry   +4 more
doaj   +1 more source