Results 101 to 110 of about 213,425 (260)

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

WCN24-909 ARTERIAL HYPERTENSION (AH) IN RENAL TRANSPLANT RECIPIENTS (RT) RISK FACTORS AND INPACT

Kidney International Reports
Ndiaga Sow, Wissal Sahtout, Awatef Azzabi, Yosra Zmanter, Sanda Mrabet, Rihem Dahmane, Ferdaous Sabri, Asma Fradi, Nesrine Thabet, Mehdi Slim, Olfa Mahfoud, Raja Boukadida, Yosra Guedri, Elias Neffeti, Narjes Ben Aicha, Dorsaf Zellama   +15 more
doaj   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

WCN25-1917 EXPANDING THE PHENOTYPIC SPECTRUM OF FABRY DISEASE: A CASE OF RENAL INVOLVEMENT IN A CARDIAC VARIANT

Kidney International Reports
Rihem Dahmane, Yosra Zmantar, Olfa Mahfoudh, Raja Boukadida, Nehed Ghenam, Roua Farhat, Narjes Ben Aicha, Wissal Sahtout, Yosra Guedri, Sanda Mrabet, Awatef Azzabi, Dorsaf Zellama   +11 more
doaj   +1 more source

Editorial: Renal fibrosis and renal transplantation. [PDF]

Front Immunol
Yang C.
europepmc   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

WCN24-19 CYTOMEGALOVIRUS (CMV) INFECTIONS AFTER RENAL TRANSPLANTATION (RT): EXPERIENCE AT CHU SAHLOUL

Kidney International Reports
Ndiaga Sow, Wissal Sahtout, Awatef Azzabi, Raja Boukadida, Sanda Mrabet, Wafa Kallela, Ferdaous Sabri, Asma Fradi, Nesrine Thabet, Rihem Dahmane, Olfa Mahfoud, Samira Ben Amor, Yosra Guedri, Abdelhalim Trabelsi, Narjes Ben Aicha, Dorsaf Zellama   +15 more
doaj   +1 more source

Urobiome composition after renal transplantation: an exploratory study. [PDF]

BMC Microbiol
Harriman D, Ng A, Bronowski M, Yang R, Dang T, Sherwood K, Nguan C, Miller A, Lange D.   +8 more
europepmc   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source