Results 131 to 140 of about 1,138,097 (292)

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

WCN24-574 PLASMA EXCHANGE: EXPERIENCE FROM THE NEPHROLOGY DEPARTMENT AT SAHLOU CHU SOUSSE. TUNISIA

Kidney International Reports
Ndiaga Sow, Awatef Azzabi, Raja Boukadida, Wissal Sahtout, Sanda Mrabet, Rihem Dahmane, Mariam Sadaoui, Asma Fradi, Nesrine Thabet, Zeinabou Dede, Nerjes Ben Aicha, Achraf Jaziri, Maha Araoud, Yosra Guedri, Olfa Mahfoud, Dorsaf Zellama   +15 more
doaj   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

WCN24-909 ARTERIAL HYPERTENSION (AH) IN RENAL TRANSPLANT RECIPIENTS (RT) RISK FACTORS AND INPACT

Kidney International Reports
Ndiaga Sow, Wissal Sahtout, Awatef Azzabi, Yosra Zmanter, Sanda Mrabet, Rihem Dahmane, Ferdaous Sabri, Asma Fradi, Nesrine Thabet, Mehdi Slim, Olfa Mahfoud, Raja Boukadida, Yosra Guedri, Elias Neffeti, Narjes Ben Aicha, Dorsaf Zellama   +15 more
doaj   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

WCN25-1917 EXPANDING THE PHENOTYPIC SPECTRUM OF FABRY DISEASE: A CASE OF RENAL INVOLVEMENT IN A CARDIAC VARIANT

Kidney International Reports
Rihem Dahmane, Yosra Zmantar, Olfa Mahfoudh, Raja Boukadida, Nehed Ghenam, Roua Farhat, Narjes Ben Aicha, Wissal Sahtout, Yosra Guedri, Sanda Mrabet, Awatef Azzabi, Dorsaf Zellama   +11 more
doaj   +1 more source

Microbiome-Targeted Modulation in Renal Transplantation. [PDF]

J Clin Med
Hau HM, Jahn N, Karitnig R, Hasenhütl SM, Sucher R, Stiegler P, Laudi S.   +6 more
europepmc   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

WCN24-19 CYTOMEGALOVIRUS (CMV) INFECTIONS AFTER RENAL TRANSPLANTATION (RT): EXPERIENCE AT CHU SAHLOUL

Kidney International Reports
Ndiaga Sow, Wissal Sahtout, Awatef Azzabi, Raja Boukadida, Sanda Mrabet, Wafa Kallela, Ferdaous Sabri, Asma Fradi, Nesrine Thabet, Rihem Dahmane, Olfa Mahfoud, Samira Ben Amor, Yosra Guedri, Abdelhalim Trabelsi, Narjes Ben Aicha, Dorsaf Zellama   +15 more
doaj   +1 more source