Results 31 to 40 of about 19,914 (203)

Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage

Exploration, EarlyView.
Osteoarthritis pain arises not only from joint damage but also from inflammation, abnormal bone changes, and excessive nerve activation inside the joint. In this study, we developed an injectable nanomedicine, LAC, that responds to the acidic environment of osteoarthritic joints to locally release two approved drugs, reducing inflammation, limiting ...
Junyan Liu, Feixiang Ding, Jiayi Li, Min Liu, Lingyu Su, Zixi Wang, Congying Pi, Shilong Jiang, Zhaokui Zeng, Changjun Li, Chao Zeng, Guanghua Lei, Kelong Ai   +12 more
wiley   +1 more source

Distal Renal Tubular Acidosis Presenting as Recurrent Paralytic Crises A Case Report

Medicine Science, 2015
Renal tubular acidosis (RTA) is a syndrome resulting from tubular dysfunction leading to deranged acid-base balance. One of the subtypes, distal RTA manifests as renal parenchymal stone disease with nephrocalcinosis, evidence of vitamin D deficiency and ...
Rupali Malik, Nabadwip Pathak
doaj   +1 more source

Resolution of proximal tubular dysfunction after liver transplantation in ATP8B1 deficiency: A case report

JPGN Reports, EarlyView.
Abstract Progressive familial intrahepatic cholestasis type 1 (PFIC1), caused by ATP8B1 deficiency, is a multisystem disorder with extrahepatic manifestations; however, renal involvement has rarely been described. We report a child with genetically confirmed PFIC1 who underwent living donor liver transplantation (LT) for progressive liver disease ...
Angela Marino, Nathalie Godefroid, Catherine De Magnée, Xavier Stephenne   +3 more
wiley   +1 more source

Distal renal tubular acidosis in Sjögren's syndrome

Saudi Journal of Kidney Diseases and Transplantation, 2018
Interstitial nephritis and immune complex-mediated glomerulonephritis are the two common renal manifestations of primary Sjögren's syndrome (SS). Here, we discuss three cases of primary SS where presenting manifestation was distal renal tubular acidosis.
Ram Narayan, Mansoor C Abdulla, Jemshad Alungal, N C Krishnadas   +3 more
doaj   +1 more source

Advancing Personalized Care for Neurogenic Bladder: The Case for Continent Urinary Diversion

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction Neurogenic lower urinary tract dysfunction (NLUTD) with a poorly compliant bladder that is refractory to minimally invasive therapies (MIT) represents an “end‐stage” phenotype in which the principal objectives are durable upper urinary tract protection and restoration of continence with acceptable long‐term morbidity.
Francis A. Jefferson, Maude E. Carmel
wiley   +1 more source

Hypokalaemia and Renal Tubular Acidosis due to Abuse of Nurofen Plus

Case Reports in Critical Care, 2012
Nurofen Plus is a common analgesic containing ibuprofen and codeine. We present a case of a 38-year-old lady who developed renal tubular acidosis with severe hypokalaemia, after chronic abuse of Nurofen Plus tablets.
M. J. Blackstock, A. Lee
doaj   +1 more source

Multifaceted burden of short bowel syndrome for patients and caregivers: The landmark survey

Nutrition in Clinical Practice, EarlyView.
Abstract Background Short bowel syndrome is a debilitating condition often requiring long‐term parenteral support to maintain hydration, nutrition, and survival. Methods As part of the noninterventional, cross‐sectional Landmark Survey study, we evaluated burdens associated with short bowel syndrome and parenteral support dependency from patient and ...
Jenny E. Harrison, Syed‐Mohammed Jafri, Roopa Vemulapalli, Vanessa Kumpf, Gail Mitchell, Mena Boules, Mindy M. Yang, Laurin Jackson, Jinyi Wang, Laurie Zografos, Daniel Wolin, Marion F. Winkler   +11 more
wiley   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Sjögren’s syndrome and hepatitis C virus infection presenting as hypokalemic quadriparesis: A case report

Journal of International Medical Research
Distal renal tubular acidosis can present with acute-onset quadriparesis caused by severe hypokalemia, and primary Sjögren’s syndrome is a significant potential cause of distal renal tubular acidosis in such patients.
Ashish Joshi, Ujjwol Prasad Risal, Navin Kumar Sah, Bhupendra Shah   +3 more
doaj   +1 more source

Hypokalemic paralysis associated with cystic disease of the kidney: case report

BMC Nephrology, 2011
Background Severe hypokalemia is known to cause muscle paralysis, and renal tubular acidosis is a recognized cause. Cystic disease of the kidney is associated with severe hypokalemia.
Jayasinghe Saroj, Rodrigo Chaturaka, Gamakaranage Champika SSSK, Rajapakse Senaka   +3 more
doaj   +1 more source