Results 51 to 60 of about 475,238 (264)

Endocrine manifestations of renal tumors; current knowledge [PDF]

Journal of Nephropathology
Renal cell carcinoma (RCC) can lead to various paraneoplastic syndromes, both endocrine and non-endocrine. Endocrine manifestations include hypercalcemia, hypertension, polycythemia, galactorrhea, Cushing’s syndrome, and alterations in glucose metabolism.
Ali Thoulfikar A. Imeer, Abdul Amir H. Kadhum, Qais R. Lahhob, Hussein Ali Al-Bahrani, Maytham Ahmed AbdulAemah, Omer Mansib Kassid   +5 more
doaj   +1 more source

Application of low‐dose CT to the creation of 3D‐printed kidney and perinephric tissue models for laparoscopic nephrectomy

Cancer Medicine, 2021
Purpose The aim of this study was to explore the feasibility of 3D printing of kidney and perinephric fat based on low‐dose CT technology. Patients and Methods A total of 184 patients with stage T1 complex renal tumors who underwent laparoscopic ...
Guan Li, Jie Dong, Zhiqiang Cao, Jinbao Wang, Dongbing Cao, Xin Zhang, Longjiang Zhang, Guangming Lu   +7 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Intraoperative Ultrasound: Bridging the Gap between Laparoscopy and Surgical Precision during 3D Laparoscopic Partial Nephrectomies

Diagnostics
The use of 3D laparoscopic partial nephrectomy has emerged as a cornerstone in the surgical arsenal for addressing renal tumors, particularly in managing challenging cases characterized by deeply seated tumors embedded within the renal parenchyma.
Ionela Mihai, Horatiu Dura, Cosmin Adrian Teodoru, Samuel Bogdan Todor, Cristian Ichim, Nicolae Grigore, Cosmin Ioan Mohor, Alin Mihetiu, George Oprinca, Nicolae Bacalbasa, Denisa Tanasescu, Dan Georgian Bratu, Adrian Boicean, Bogdan Oros, Adrian Hasegan   +14 more
doaj   +1 more source

Papillary renal adenoma in a toco toucan (Ramphastos toco)

Brazilian Journal of Veterinary Pathology, 2018
Primary renal neoplasms are infrequent in domestic animals and birds, being budgerigars an exception. This report describes a papillary renal adenoma in a toco toucan (Ramphastos toco), which was euthanized due to poor prognosis after surgical ...
Alexandre Arenales, Frank A. de O. Toledo, Ayisa R. de Oliveira, Nayara F. de Paula, Lucas B. S. de Oliveira, Carlyle M. Coelho, Herlandes P. Tinoco, Renato L. Santos   +7 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source