Results 201 to 210 of about 23,687 (258)

Humans can rebuild severely eroded resilience: Demo with millennia-long records in China's Loess Plateau. [PDF]

PNAS Nexus
Zhang XJ, Chen J, Liu G.
europepmc   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Embracing complexity by reducing rigidity: guiding principles for the intersection of implementation science and qualitative research. [PDF]

Implement Sci
Sheard L, Reisinger H, Beidas R, Wilson P.   +3 more
europepmc   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

What are citizens' concerns in urban regeneration? Exploring critical factors for participatory intention, a case from Shanghai. [PDF]

Front Psychol
Li Y, Wei Q, Guo J, Song Y, Wu X.
europepmc   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Adaptive Expertise of College English Teachers in the Era of Artificial Intelligence: A Grounded Theory Approach. [PDF]

Behav Sci (Basel)
Zhou Q, Hu L, Zou X, Zhang X.
europepmc   +1 more source

The role of pluripotency regulators in triple-negative breast cancer immune response. [PDF]

Front Genet
López-Santana C, Mendez-Rivera F, Bernal-Estévez DA.   +2 more
europepmc   +1 more source

Historical change and spatial relation of cultural memory in Guangzhou from the perspective of heritage representation. [PDF]

Sci Rep
Liao Z, Yang H.
europepmc   +1 more source

The integrated theory of carcinogenesis: cancer as dysregulated persistence under chronic systemic stress. [PDF]

Front Oncol
Kopp W.
europepmc   +1 more source