Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng +5 more
wiley +1 more source
<i>"You're never going to get a second chance if someone doesn't give you a second chance"</i> perspectives and experiences of landlords and advocates on implementing HOME among youth experiencing homelessness. [PDF]
Rose DM +9 more
europepmc +1 more source
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong +4 more
wiley +1 more source
Opportunity cost estimates for spatial conservation prioritisation across terrestrial Europe. [PDF]
Spencer D +10 more
europepmc +1 more source
Hierarchical PP–LSR107–BaTiO3 nanocomposite films are fabricated by one‐step extrusion and stretching for roll‐to‐roll manufacture, combining high energy storage and processing flexibility. LSR107 surrounds BaTiO3‐rich regions, locating amorphous PP, decreasing defects, and introducing deep traps that homogenize the electric field and suppress charge ...
Yi Gao +14 more
wiley +1 more source
Unmet social needs in pediatric rheumatic disease: a study of disparities. [PDF]
Ciaglia K, Moosa H, Ma Y, Sloan EE.
europepmc +1 more source
Constructing Seamless Interfaces for Ultrastable Flexible Supercapacitors
Seamless electrode/electrolyte and electrolyte/electrolyte interfaces with boosted interfacial toughness and adhesion are constructed by anchored interfacial polymerization and in situ polymerization, respectively. The achieved supercapacitor exhibits ultrahigh capacitance retention over 100,000 times of charge/discharge or folding deformation ...
Keyi Dong +8 more
wiley +1 more source
Exploring the association between housing insecurity and mental health among renters: A systematic review of quantitative primary and secondary studies. [PDF]
Talmatzky M +3 more
europepmc +1 more source
Progress in Strain Engineering of 2D‐Integrated Heterostructures for Ultrasensitive Sensors
. ABSTRACT Two‐dimensional (2D) integrated heterostructures have emerged as a cornerstone in the advancement of next‐generation sensor technologies. These heterostructures, which combine materials with different dimensionalities, have led to significant breakthroughs in sensing performance and device integration.
That Buu Ton +4 more
wiley +1 more source

