Results 191 to 200 of about 143,291 (315)

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Factors associated with psychological wellbeing, is education one of them? [PDF]

PLoS One
Oskrochi G, Oskrochi Y, Eskrootchi R.
europepmc   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Rent as a toxic exposure: The Bronx and Manhattan. [PDF]

Public Health Pract (Oxf)
Wallace D.
europepmc   +1 more source

Breaking the Trade‐Off of Mechanical Robustness and Energy Storage Capacity in Phase Change Materials Through a Molecular Design Strategy of Hard‐Segment‐Anchored/Side‐Chain‐Storage

Advanced Science, EarlyView.
To decouple mechanical robustness and energy storage capacity in phase change materials (PCMs), a series of polyurethane‐based PCMs bearing crystallizable alkyl side chains are synthesized via a hard‐segment‐anchored/side‐chain‐storage molecular design.
Huizhou Luo, Hebo Shi, Jun Zhang, Henghui Deng, Yongyin Zhu, Zehong Chen, Chaoqun Zhang   +6 more
wiley   +1 more source

The prospective relationship between uptake of earned income tax credit (EITC), financial strain, and health in socio-economically strained families of Arab-American descent. [PDF]

BMC Public Health
Arnetz BB, Grinstead A, Thomas G, Hetherwick M, Ma W, Arble E, Kabalan M, Cole A, Arnetz JE, Ayoub R.   +9 more
europepmc   +1 more source

A Review of Failure Modes and Safety Strategies of Lithium‐Ion Batteries from Materials to Systems

Advanced Science, EarlyView.
A cascade‐aware framework is presented for lithium‐ion battery safety, linking thermal runaway initiation, acceleration, runaway reaction, and propagation with material‐, cell/pack‐, and system‐level interventions. By integrating failure mechanisms, quantitative safety indicators, and staged interception strategies, this review highlights how safer ...
Jin Hyeok Yang, Jae Yoon Sung, Hyunji Kweon, Seohyun Kim, Byunghoon Kim, Jongsoon Kim, Junyoung Mun, Jung Ho Kim, Ki Jae Kim   +8 more
wiley   +1 more source

Anesthetic Management of Penetrating Tracheal Injury in a 3-Year-Old Child: A Case Report. [PDF]

Ann Card Anaesth
Indira M, Geeta A, Venkata KTM, Manasmita D, Disha G, Prakash C.   +5 more
europepmc   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source