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Oncolytic Viral Therapy Using Reovirus
2009Current mainstays in cancer treatment such as chemotherapy, radiation therapy, hormonal manipulation, and even targeted therapies such as trastuzumab (Herceptin) for breast cancer or erlotinib (Tarceva) for non-small cell lung cancer are limited by lack of efficacy, cellular resistance, and toxicity.
Chandini, Thirukkumaran, Don G, Morris
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Pathogenesis of Reovirus Myocarditis
1998Acute myocarditis (Aretz et al. 1986) is prevalent in humans, with reports suggesting that 5%–20% of the population has suffered some form of viral myocarditis (Bandt et al. 1979; Okuni et al. 1975; Woodruff 1980). It is often fatal in infants (Cherry 1995; Kaplan et al. 1983; Martin et al. 1994). In older individuals the acute disease usually resolves
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1998
The µ2 protein, along with the polymerase protein λ3, is present in catalytic amounts in virions (approximately 12 copies) and may be positioned at the inner face of the vertices of the inner capsid (Nibert et al. 1996). Since µ2 protein, along with λ3, is the least abundant viral protein, it was missed in the original studies that examined reovirus ...
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The µ2 protein, along with the polymerase protein λ3, is present in catalytic amounts in virions (approximately 12 copies) and may be positioned at the inner face of the vertices of the inner capsid (Nibert et al. 1996). Since µ2 protein, along with λ3, is the least abundant viral protein, it was missed in the original studies that examined reovirus ...
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Journal of Neuropathology and Experimental Neurology, 1970
George Margolis, Lawrence Kilham
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George Margolis, Lawrence Kilham
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