Results 221 to 230 of about 3,036,040 (301)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Immediate Repair for Laceration of the Tunica Albuginea of the Corpora Cavernosa and Penile Urethral Injury Caused by Blunt Trauma to the Flaccid Penis: A Case Report. [PDF]

IJU Case Rep
Fujimura R, Ishiura Y, Kurauchi D, Shimada T, Naito R, Iwamoto H, Niikura S, Mizokami A.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Neglected Ruptures of the Patellar Tendon: Report of Three Cases in the Orthopedic Trauma Department of Dalal Jamm Hospital, Dakar. [PDF]

J Orthop Case Rep
Diop M, Sow M, Dembele B, Daffé M, Diop B, Sané AD.   +5 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Rethinking meniscal repair in patients over 40: Extending the boundaries of joint preservation. [PDF]

World J Methodol
Lim Y, Lim WB, Bonner T, Wood L, Volpin A.   +4 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Lateral meniscus posterior root repair during ACL reconstruction restores knee stability and results in outcomes comparable to isolated ACL reconstruction: A propensity-matched cohort analysis. [PDF]

J Exp Orthop
Koukoulias N, Avram GM, Germanou EI, Koukoulias D, Graikos G, Vasiliadis A, Tsifountoudis I, Dimitriadis T.   +7 more
europepmc   +1 more source