Results 31 to 40 of about 480,328 (233)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

Extending Construction X for Quantum Error-Correcting Codes [PDF]

open access: yes, 2013
In this paper we extend the work of Lisonek and Singh on construction X for quantum error-correcting codes to finite fields of order $p^2^ where p is prime.
Degwekar, Akshay   +2 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Uniform constant composition codes derived from repeated‐root cyclic codes

open access: yesElectronics Letters, 2018
Uniform constant composition (UCC) codes are introduced, which are p ‐ary constant composition codes with block length mp where each p ‐ary symbol appears exactly m times in
V.C. da Rocha   +2 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assessment Report 2012 Top of the World, Bangladesh AA0000000133 [PDF]

open access: yes, 2012
This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide.
Fair Labor Association
core   +1 more source

Squaring Construction For Repeated-Root Cyclic Codes

open access: yes, 2010
{"references": ["E. Rains and N.J.A. Sloane, \"Self-dual codes,\" in Handbook of Coding\nTheory, V.S. Pless and W.C. Huffman (Editors), Elsevier, Amsterdam,\npp. 177-294, 1998.", "J. H. Conway and V. Pless, \"On the enumeration of self-dual codes,\" J.\nCombinatorial Theory, 28A, 26-53, 1980.", "F. J. MacWilliams and N. J. A.
O. P. Vinocha   +2 more
openaire   +1 more source

Home - About - Disclaimer - Privacy