Results 41 to 50 of about 480,328 (233)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

ANALYZING BIG DATA WITH DECISION TREES [PDF]

open access: yes, 2014
ANALYZING BIG DATA WITH DECISION ...
Leong, Lok Kei
core   +1 more source

Repeated-root constacyclic codes of length $ 3\ell^mp^s $

open access: yesAdvances in Mathematics of Communications, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Liu, Yan   +3 more
openaire   +2 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Assessment Report 2014 KTC Limited, China AA0000000364 [PDF]

open access: yes, 2014
This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide.
Fair Labor Association
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Self-dual repeated root cyclic and negacyclic codes over finite fields [PDF]

open access: yes2012 IEEE International Symposium on Information Theory Proceedings, 2012
In this paper we investigate repeated root cyclic and negacyclic codes of length $p^rm$ over $\mathbb{F}_{p^s}$ with $(m,p)=1$. In the case $p$ odd, we give necessary and sufficient conditions on the existence of negacyclic self-dual codes. When $m=2m'$ with $m'$ odd, we characterize the codes in terms of their generator polynomials.
Guenda, Kenza, Gulliver, T. Aaron
openaire   +2 more sources

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