Results 61 to 70 of about 520,695 (298)

AD in Fortran, Part 1: Design [PDF]

open access: yes, 2012
We propose extensions to Fortran which integrate forward and reverse Automatic Differentiation (AD) directly into the programming model. Irrespective of implementation technology, embedding AD constructs directly into the language extends the reach and ...
Pearlmutter, Barak A.   +2 more
core   +1 more source

Self-dual repeated root cyclic and negacyclic codes over finite fields [PDF]

open access: yes2012 IEEE International Symposium on Information Theory Proceedings, 2012
In this paper we investigate repeated root cyclic and negacyclic codes of length $p^rm$ over $\mathbb{F}_{p^s}$ with $(m,p)=1$. In the case $p$ odd, we give necessary and sufficient conditions on the existence of negacyclic self-dual codes. When $m=2m'$ with $m'$ odd, we characterize the codes in terms of their generator polynomials.
Guenda, Kenza, Gulliver, T. Aaron
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Note on islands in path-length sequences of binary trees [PDF]

open access: yes, 2014
An earlier characterization of topologically ordered (lexicographic) path-length sequences of binary trees is reformulated in terms of an integrality condition on a scaled Kraft sum of certain subsequences (full segments, or islands).
Foldes, S.   +3 more
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

One-Sided Repeated-Root Two-Dimensional Cyclic and Constacyclic Codes [PDF]

open access: green, 2022
Marziyeh Beygi Khormaei   +2 more
openalex   +1 more source

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