Results 51 to 60 of about 2,012,640 (258)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Squaring Construction For Repeated-Root Cyclic Codes

, 2010
{"references": ["E. Rains and N.J.A. Sloane, \"Self-dual codes,\" in Handbook of Coding\nTheory, V.S. Pless and W.C. Huffman (Editors), Elsevier, Amsterdam,\npp. 177-294, 1998.", "J. H. Conway and V. Pless, \"On the enumeration of self-dual codes,\" J.\nCombinatorial Theory, 28A, 26-53, 1980.", "F. J. MacWilliams and N. J. A.
O. P. Vinocha, J. S. Bhullar, Manish Gupta   +2 more
openaire   +1 more source

Decoding of repeated-root cyclic codes up to new bounds on their minimum distance

, 2015
The well-known approach of Bose, Ray-Chaudhuri, and Hocquenghem and its generalization by Hartmann and Tzeng are lower bounds on the minimum Hamming distance of simple-root cyclic codes.
Zeh, Alexander, Ulmschneider, Markus
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Oscillator-Embedded Analog Baseband Filter Design Enabling Frequent and Cost-Efficient 3-dB Frequency Calibration for Wireless Transceiver Applications

IEEE Access
Accurate calibration of the 3-dB bandwidth of analog baseband (ABB) filters is critical in modern wireless transceivers. Existing replica-based and loopback-based calibration methods require substantial auxiliary hardware, impose matching constraints, or
Kyudong Kim, Jaeeun Jang
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Changes and contributions to the gender pay gap in surgery in Canada: a repeated cross-sectional analysis from 1996 to 2020

BMJ Open
Objectives Occupational gender segregation is a contributing factor to gender pay inequity in medicine but has not been thoroughly characterised. We assessed the historical relationship between surgeon sex, type of work and value of procedural payments ...
Tara Kiran, Rahim Moineddin, Fahima Dossa, Michelle Cohen   +3 more
doaj   +1 more source