Results 311 to 320 of about 1,635,028 (357)

Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis

Advanced Science, EarlyView.
Fumadó Navarro et al. present an optimized strategy to generate vascular‐like networks that infiltrate within cerebral organoids with promising signs of blood‐brain barrier characteristics, preserved stiffness, uniform morphology, enhanced media diffusion, and reduced necrotic core.
Josep Fumadó Navarro, Siobhan Crilly, Wai Kit Chan, Shane Browne, John O. Mason, Catalina Vallejo‐Giraldo, Abhay Pandit, Mihai Lomora   +7 more
wiley   +1 more source

Picking strategies in games of cooperation. [PDF]

Proc Natl Acad Sci U S A
García J, Traulsen A.
europepmc   +1 more source

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

Advanced Science, EarlyView.
Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao, Jiao‐Jiao Zhang, Meng‐Qi You, Han Wang, Yan Lin, Yuan Fang, Hui‐Lu Zhang, Yuan‐Yuan Qu, Qian Zhou, Meng Wang, Gang Li, Zi‐Fan Guo, Meng Xu, Jie Liu, Peng‐Cheng Lin, Yi‐Yuan Yuan, Yu Kang, Shi‐Min Zhao, Wei Xu   +18 more
wiley   +1 more source

Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells

Advanced Science, EarlyView.
The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Jiefeng Huang, Ke Fang, Wuyan Lu, Rongrong Wu, Yuanyuan Chen, Linxiao Li, Zihao Hu, Zixin Cai, Yu Jiang, Xinli Fan, Jinyi Deng, Guangpeng Liu, Zhuang Luo, Lei Cui, Shuaijun Li   +14 more
wiley   +1 more source

Can Maturation Level Influence Long-Term Physiological and Physical Adaptations in Youth Female Soccer Players Exposed to Combined Sided Games and HIIT? A Comparison Across Maturation Statuses. [PDF]

J Sports Sci Med
Zhou Y, Liu J, Yang L, Zheng B.
europepmc   +1 more source

Peptide Electrostatic Modulation Directs Human Neural Cell Fate

Advanced Science, EarlyView.
This study explores the effect of charge on the bioactivity of peptide‐based supramolecular materials. The design of a peptide library with varying charges that self‐assemble into supramolecular fibers is presented, demonstrating how the surface charge of these fibers, used as artificial extracellular matrices, influences the fate of human neural ...
Laura Perez‐Chirinos, Xavier Barceló, M. Gabriella Chiariello, Irene Sanz, Amaia Iturrospe, Arantxa Arbe, J. Alberto Ortega, Siewert J. Marrink, Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli   +10 more
wiley   +1 more source

Effectiveness of Gamified Teaching in Disaster Nursing Education for Health Care Workers: Systematic Review.

J Med Internet Res
Bai S, Zeng H, Zhong Q, Cao L, He M.
europepmc   +1 more source

Mobile app-based cognitive decision-making and memory games enhance cognitive function in older adults with mild cognitive impairment. [PDF]

Front Psychol
Pumpho A, Boonsinsukh R, Srisim K, Kaewsanmung S, Suwannarat P, Keawduangdee P.   +5 more
europepmc   +1 more source

Stable strategies of direct and indirect reciprocity across all social dilemmas. [PDF]

PNAS Nexus
Hübner V, Schmid L, Hilbe C, Chatterjee K.   +3 more
europepmc   +1 more source

Effects of High-Intensity Interval Training with Change of Direction Versus Small-Sided Games on Physical Fitness in School-Aged Children. [PDF]

Children (Basel)
Bibić E, Stupar D, Mitrović N, Zoretić D, Trajković N.   +4 more
europepmc   +1 more source