Results 101 to 110 of about 3,681,265 (301)
Statistical Methods for Assessing Diagnostic Agreement
Applied SciencesWith the rise of artificial intelligence (AI), an increasing number of AI-based diagnostic tools are being developed. Before clinical implementation, these tools must be validated against existing gold standards.
Maximilian Pilz
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Efficient conjoint choice designs in the presence of respondent heterogeneity. [PDF]
The authors propose a fast and efficient algorithm for constructing D-optimal conjoint choice designs for mixed logit models in the presence of respondent heterogeneity.
Goos, Peter +2 more
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Data fusion for timber bundle volume measurement
, 2019 In many industrial fields, the direct measurement of a specific parameter of interest can be too costly to be feasible. Using data from other parameters about the process, a data driven approach can instead be used for a cost-efficient estimation of the ...
Liguori C. +4 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Minimal balanced repeated measurements designs
, 2010 Experimental designs in which treatments are applied to the experimental units, one at a time, in sequences over a number of periods, have been used in several scientific investigations and are known as repeated measurements designs.
Cini Varghese, V. K. Sharma, Seema Jaggi
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
BMC PsychiatryBackground Children with autism spectrum disorder (ASD) often struggle with eye contact during social interactions, a key aspect of effective communication.
Şenol Demirtaş, Metin Besalti
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Aligned Rank Statistics for Repeated Measurement Models with Orthonormal Design, Employing a Chernoff-Savage Approach [PDF]
AMS classifications: 62G10, 62G20; 62J05.aligned rank statistics;orthonormal design matrix;repeated measurements;Chernoff-Savage ...
Einmahl, J.H.J. +3 more
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