Results 151 to 160 of about 2,168,210 (298)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Short-Term Exposure to PM_2.5 and O₃ Impairs Liver Function in HIV/AIDS Patients: Evidence from a Repeated Measurements Study. [PDF]

Toxics, 2023
Ma H, Zhang Q, Liang W, Han A, Xie N, Xiang H, Wang X.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

TWO-SAMPLE TESTS FOR MULTIVARIATE REPEATED MEASUREMENTS OF HISTOGRAM OBJECTS WITH APPLICATIONS TO WEARABLE DEVICE DATA. [PDF]

Ann Appl Stat, 2022
Zhang J, Merikangas KR, Li H, Shou H.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Análisis de la evolución en el tiempo para datos con estructura de grupos: STATIS dual canónico y modelo de medidas repetidas doblemente multivariantes Analysis of Time Evolution for Group Structured Data: Canonical Dual STATIS and Doubly Multivariate Repeated Measures Model

Revista Colombiana de Estadística, 2008
En este trabajo proponemos dos soluciones al problema que se plantea cuando se pretende analizar datos multivariantes, para un conjunto de individuos con estructura de grupos, que además han sido replicados bien sea en ocasiones o en situaciones ...
AMPARO VALLEJO, JOSÉ LUIS VICENTE, PURIFICACIÓN GALINDO, MARGARITA FERNÁNDEZ, CAMINO FERNÁNDEZ, ELOY BÉCARES   +5 more
doaj  

The HOME-Health (HOusing, environMEnt, and Health) Study; Description of a Danish natural experiment, designed as a longitudinal study with repeated measurements, providing internal- and external validity of the study. [PDF]

Environ Health Insights, 2023
Gabel C, Elholm G, Rasmussen MK, Broholt TH, Jensen SR, Petersen S, Sigsgaard T.   +6 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Association of longitudinal repeated measurements of frailty index with mortality: Cohort study among community-dwelling older adults. [PDF]

EClinicalMedicine, 2022
Li X, Schöttker B, Holleczek B, Brenner H.   +3 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source