Results 71 to 80 of about 4,658,486 (302)

Classification Rules for Multivariate Repeated Measures Data with Equicorrelated Correlation Structure on both Time and Spatial Repeated Measurements [PDF]

We study the problem of classi¯cation for multivariate repeated measures data with struc- tured correlations on both time and spatial repeated measurements. This is a very important problem in many biomedical as well as in engineering ¯eld. Classi¯cation
Ricardo Leiva, Anuradha Roy
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study

Metabolites
Studies examining long-term longitudinal metabolomic data and their reliability in large-scale populations are limited. Therefore, we aimed to evaluate the reliability of repeated measurements of plasma metabolites in a prospective cohort setting and to ...
Atsuko Miyake, Sei Harada, Daisuke Sugiyama, Minako Matsumoto, Aya Hirata, Naoko Miyagawa, Ryota Toki, Shun Edagawa, Kazuyo Kuwabara, Tomonori Okamura, Asako Sato, Kaori Amano, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Kazuharu Arakawa, Toru Takebayashi, Miho Iida   +18 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Validity and Reliability of the Posturographic Outcomes of a Portable Balance Board

Sensors
In view of the frequent use of the portable balance board (Tymo®, Tyromotion, Graz, Austria) in neurorehabilitation, the objective of this study is to assess its posturographic validity and reliability in comparison to a floor-embedded force platform ...
Patricia Meier, Maité Calisti, Inge Werner, Daniel Debertin, Lukas Mayer-Suess, Michael Knoflach, Peter Federolf   +6 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Reliability parameters of repeated measurements of RBP4 and omentin-1.

, 2015
Coefficient of variation (CV) and intraclass correlation coefficient (ICC) of repeated biomarker measurementsaRBP4: retinol-binding protein 4.bBMI: body mass index.cBP: blood pressure.Reliability parameters of repeated measurements of RBP4 and omentin-1.
Matthias B. Schulze (125913), Cornelia Weikert (122094), Ronald Biemann (799599), Clemens Wittenbecher (799598), Krasimira Aleksandrova (122093), Romina di Giuseppe (122091), Maria Arregui (122086), Juliane Menzel (799600), Heiner Boeing (23585), Berend Isermann (526770), Juliane Hoffmann (799601)   +10 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source