Results 111 to 120 of about 4,206,856 (305)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Sensitivity analysis and uncertainty quantification of stiffness modulus using indirect tensile test

International Journal of Applied Mechanics and Engineering
The stiffness modulus is a critical element in pavement engineering, as its accurate measurement directly reflects the load-bearing capacity of the pavement section.
Hicham Mezouara, Houcine Zniker, Ikram Feddal, Mohammed Khalil El Kouifat, Mohamed El Hasnaoui   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

EFFECT OF PHYSICAL ACTIVITY INTERVENTION ON COGNITIVE DEVELOPMENT IN AUTISM SPECTRUM DISORDER

Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi
Electroencephalography (EEG) signals are frequently used in mental workload assessments. Therefore, spectral analysis in Autism Spectrum Disorder (ASD) is considered necessary to shed light on the aetiology, to develop intervention programs to reduce ...
Sevim Akşit, Bülent Ağbuğa
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Aligned Rank Statistics for Repeated Measurement Models with Orthonormal Design, Employing a Chernoff-Savage Approach [PDF]

AMS classifications: 62G10, 62G20; 62J05.aligned rank statistics;orthonormal design matrix;repeated measurements;Chernoff-Savage ...
Einmahl, J.H.J., Puri, M.L., Ruymgaart, F.H., Omolo, B.O.   +3 more
core  

Biomonitoring 3.0: Beyond Taxa Lists to Evidence‐Tiered Monitoring of Ecosystem Dynamics and Interactions

Ecology and Evolution
High‐throughput sequencing has transformed biomonitoring by enabling scalable molecular inventories, but most programs still emphasize taxa lists. In this Perspective, Biomonitoring 3.0 is proposed as a framework that builds on molecular inventories to ...
Leandro Lofeu, Ehsan Pashay Ahi
doaj   +1 more source