Results 91 to 100 of about 4,206,856 (305)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

On the treatment of repeated observations in panel data: efficiency of mixed logit parameter estimates [PDF]

, 2011
Travel demand models are often estimated using cross-sectional data. Although the use of panel data has recently increased in many areas, there are still many aspects that have not been analyzed fully.
Heydecker, B.G., Cherchi, E., Yáñez, M.F., Ortúzar, J.d.-D.   +3 more
core  

Commissioning and Assessment of Radiation Field and Dose Inhomogeneity for a Dual X-ray Tube Cabinet Irradiator: To Ensure Accurate Dosimetry in Radiation Biology Experiments

Advances in Radiation Oncology
Purpose: Standardization of x-ray cabinet irradiator dose, geometry, and calibration reporting is an ongoing process. Multi-tube designs have been introduced into the preclinical market and give a theoretical benefit but have not been widely assessed for
Mitchell Polizzi, MS, Kristoffer Valerie, PhD, Siyong Kim, PhD   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Classification Rules for Multivariate Repeated Measures Data with Equicorrelated Correlation Structure on both Time and Spatial Repeated Measurements [PDF]

We study the problem of classi¯cation for multivariate repeated measures data with struc- tured correlations on both time and spatial repeated measurements. This is a very important problem in many biomedical as well as in engineering ¯eld. Classi¯cation
Ricardo Leiva, Anuradha Roy
core  

Event-Triggered Adaptive Consensus Control for Nonlinear Multi-Agent Systems with Prescribed Performance and Full-State Constraints

Sensors
This work addresses the output agreement problem for networked nonlinear agents with simultaneous transient performance specifications and state limitations.
Wenjie Wang, Qian Chen, Huiying Xu, Zhendong Chen, Longfei Wang, Deang Su, Xinzhong Zhu   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

On the Effect of High Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on the Reduction of BAS Intensity in Methamphetamine Abusers [PDF]

Research on Addiction, 2016
Objective: The present study was an attempt to examine the effect of repetitive Transcranial magnetic stimulation (rTMS) on the reduction of Behavioral Activation System's activity in right and left dorsolateral prefrontal cortex among methamphetamine ...
nastaran Mansouroyeh, reza rostami, majid aliloo   +2 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Meta-Problem in Scientific Research in Physical Education and Sport: Architecture and Pathways to Knowledge

Physical Education Theory and Methodology
Purpose. To systematize approaches to understanding the meta-problem and its operationalization in research on physical education and sport. Materials and Methods.
Oleg Khudolii, Olha Ivashchenko, Mykola Khudolii   +2 more
doaj   +1 more source