Results 41 to 50 of about 4,206,856 (305)

On optimality and construction of circular repeated-measurements designs [PDF]

, 2017
The aim of this paper is to characterize and construct universally optimal designs among the class of circular repeated-measurements designs when the parameters do not permit balance for carry-over effects. It is shown that some circular weakly neighbour
Bailey, Rosemary Anne, Kunert, Joachim, Filipiak, Katarzyna, Markiewicz, Augustyn, Cameron, Peter Jephson   +4 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Can measurement of glucose levels in blood and peritoneal fluid be used to diagnose septic peritonitis in dogs?

Veterinary Evidence, 2022
PICO question Can the measurement of blood and peritoneal fluid effusion glucose levels be used to accurately diagnose septic peritonitis in dogs when compared to cytology and bacterial culture?
Nicole D'Mello
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Designing stepped wedge trials to evaluate physical activity interventions in schools: methodological considerations

International Journal of Behavioral Nutrition and Physical Activity
Background In a stepped wedge design, schools are randomised to a sequence of measurements, with each sequence transitioning to intervention status at a different time.
Ruth Salway, Danielle House, Simona Kent-Saisch, Robert Walker, Lydia Emm-Collison, Alice Porter, David R Lubans, Michael Beets, Frank de Vocht, Russell Jago   +9 more
doaj   +1 more source

Studies on Reliability and Measurement Error of Measurements in Medicine – From Design to Statistics Explained for Medical Researchers

Patient Related Outcome Measures, 2023
Lidwine B Mokkink,1,2 Iris Eekhout,1– 3 Maarten Boers,1,2 Cees PM van der Vleuten,4 Henrica CW de Vet1,2 1Amsterdam UMC, Vrije Universiteit Amsterdam, Epidemiology and Data Science, Amsterdam, the Netherlands; 2Amsterdam Public Health Research Institute,
Mokkink LB, Eekhout I, Boers M, van der Vleuten CP, de Vet HC   +4 more
doaj  

The study design elements employed by researchers in preclinical animal experiments from two research domains and implications for automation of systematic reviews.

PLoS ONE, 2018
Systematic reviews are increasingly using data from preclinical animal experiments in evidence networks. Further, there are ever-increasing efforts to automate aspects of the systematic review process.
Annette M O'Connor, Sarah C Totton, Jonah N Cullen, Mahmood Ramezani, Vijay Kalivarapu, Chaohui Yuan, Stephen B Gilbert, Stephen B Gilbert   +7 more
doaj   +1 more source

Memory Effects in Repeated Survey Questions: Reviving the Empirical Investigation of the Independent Measurements Assumption

Survey Research Methods, 2020
It is common to repeat survey questions in the social sciences, for example to estimate test-retest reliability or in pretest-posttest experimental designs.
Hannah Schwarz, Melanie Revilla, Wiebke Weber   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source