Results 51 to 60 of about 2,612,449 (235)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Deterministic Area Coverage by UAV Swarms via Multi-Eulerian Rotor-Router Walks
Mathematical Problems of Computer ScienceThe deterministic area coverage problems for UAV swarms based on multi-Eulerian rotor-router walks are investigated. The rotor-router model provides a quasi-random analogue of random walks with strong structural properties. The loop reversibility theorem
V. Poghosyan
semanticscholar +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Current Issues in Sport ScienceIntroduction & Purpose Acute high temperatures and physical activity induce physiological and psychophysiological stress (Périard et al., 2021). In athletes or professions like firefighting, core body temperatures often exceed 38.5 °C (Barr et al ...
Jannic Wälde +3 more
doaj +1 more source
Non-Backtracking Random Walks and a Weighted Ihara’s Theorem [PDF]
, 2017 We study the mixing rate of non-backtracking random walks on graphs by looking at non-backtracking walks as walks on the directed edges of a graph. A result known as Ihara’s Theorem relates the adjacency matrix of a graph to a matrix related to non ...
Kempton, Mark Condie
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
How do people predict a random walk? Lessons for models of human cognition.
Psychology ReviewRepeated forecasts of changing values are common in many everyday tasks, from predicting the weather to financial markets. A particularly simple and informative instance of such fluctuating values are random walks: Sequences in which each point is a ...
Jake Spicer +3 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source