Results 91 to 100 of about 181,215 (307)

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

Journal of the American College of Cardiology, 2015
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2 processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the last 3 decades, therapies to reduce ischemic injury (mainly reperfusion strategies) have been widely incorporated into clinical practice.
Ibanez, B., Heusch, G., Ovize, Michel, Werf, F.   +3 more
openaire   +3 more sources

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

Thrombolytic Therapy Up-regulates Inflammatory Mediators Compared to Percutaneous Coronary Intervention (PCI)

Iranian Journal of Allergy, Asthma and Immunology, 2016
The important role of reperfusion therapies in the treatment of acute myocardial infarction is well documented. However, reperfusion therapies can initiate inflammatory response and may damage the myocardium.
Alireza Garjani, Bahram Sohrabi, Ali Akbar Movassaghpour, Sina Andalib, Mehriar Shokri, Bahar Taherkhanchi, Bahador Bagheri   +6 more
doaj  

Plasma from Volunteers Breathing Helium Reduces Hypoxia-Induced Cell Damage in Human Endothelial Cells-Mechanisms of Remote Protection Against Hypoxia by Helium. [PDF]

, 2019
PurposeRemote ischemic preconditioning protects peripheral organs against prolonged ischemia/reperfusion injury via circulating protective factors. Preconditioning with helium protected healthy volunteers against postischemic endothelial dysfunction.
Augustijn, Quinten JJ, Hollmann, Markus W, Konkel, Moritz, Oei, Gezina TML, Patel, Hemal H, Preckel, Benedikt, Smit, Kirsten F, Weber, Nina C   +7 more
core   +1 more source

Substantially Altered Local and Systemic Immunity in Ischemia‐Free Versus Conventional Liver Transplantation

Advanced Science, EarlyView.
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo, Shuai He, Shirui Chen, Dongmei Ye, Shibo Zhang, Di Liu, Dawei Zou, Linhe Wang, Huadi Chen, Jinghong Xu, Huanjie Liu, Ruiting Liu, Xi Tan, Yitong Wang, Jiayi Zeng, Runbing Mo, Yuexin Li, Yuyi Zhang, Tanyiyang Ruan, Tielong Wang, Zehua Jia, Yu Jia, Tongdi Fang, Yimou Lin, Xiaorui Liu, Yunhua Tang, Maogen Chen, Qiang Zhao, Anbin Hu, Weiqiang Ju, Yi Ma, Dongping Wang, Xiaofeng Zhu, Schlegel Andrea, Yuan Zhai, Kwan Man, Tullius G. Stefan, Yifang Gao, Jinxin Bei, Xiaoshun He, Zhiyong Guo   +40 more
wiley   +1 more source

Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries [PDF]

, 2017
Aims Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in patients ...
Agladze, Vaja, Alexopoulos, Dimitrios, Alhabib, Khalid F., Almeida, Manuel, Antoniades, Loizos, Antov, S., Babic, Z., Becker, David, Birkhead, John, Bjornsdottir, Thora K., Bovenzi, Francesco, Cavanagh, Brendan, Christodulides, Theodoros, Claeys, Marc J., Clemmensen, Peter, Cremonesi, Alberto, D'Angeli, Cinzia, Daly, Kieran, De Boer, Menko-Jan, De Luca, Leonardo, Deleanu, Dan, Di Mario, Carlo, Dobric, Milan, Dudek, Dariusz, Erglis, Andrejs, Erne, Paul, Ertas, Gokhan, Fajadet, Jean, Galatius, Søren, Georgiou, Panagiota, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, Gudnason, Thorarinn, Hajric, R., Hansen, Kim Wadt, Hricak, V., Huber, Kurt, James, Stefan, Janota, Tomáš, Jansky, Petr, Jennings, Siobhan, Jorgova, Julia, Kaifoszova, Zuzana, Kajander, Olli, Kala, Petr, Kallikazaros, Ioannis, Kanakakis, John, Karamfiloff, Kiril K., Kedev, Sasko, Kervan, Umit, Kiss, Robert Gabor, Koch, Karel T., Kornowski, Ran, Kovař, F., Kozan, Omer, Kristensen, Steen D., Kurray, P., Laut, Kristina G., Legrand, V., Ludman, Peter F., Maca, Aija, Markota, D., Matetzky, Shlomi, Merkely, Béla, Milicic, Davor, Mimoso, Jorge, Mühlberger, Volker, Müller, Alfred, Najafov, Ruslan, Najafov, Ruslan, Narbute, Inga, Nedeljkovic, Milan, Nicolaides, Evagoras, Nicolini, Francesca A., Nikolic Heitzler, V., Noč, Marko, Ostojic, Miodrag, Papaioannou, Georgios, Peral, Vincente, Pereira, Ernesto, Pereira, Hélder, Petrov, Ivo, Radovanovic, Dragana, Regueiro, Ander, Rickli, Hans, Romppanen, Hannu, Rustige, Jörg, Sabaté, Manel, Shal, Ahmed El, Skuladottir, Frida Bjork, Sobhy, Mohamed, Sobhy, Mohamed, Sokolov, Maxim, Sokolov, Yuriy, Spuzic, M., Srdic, S., Stasek, Josef, Studencan, Martin, Sørensen, Rikke, Tatu, Gabriel, Terkelsen, Christian Juhl, Terzic, Ibrahim, Tresserras, Ricard, Twomey, Kathleen, Ungi, Imre, Velchev, Vassil, Vinereanu, Dragos, Vukcevic, Vladan, Wahler, Steffen, Widimsky, Petr, Wijns, William, Windecker, Stephan, Zakke, IIja   +113 more
core  

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source

Anti-inflammatory Therapy Before Reperfusion Therapy in Patients with Ischemic Vascular Disease on the Incidence of Ischemic Reperfusion Injury: An Evidence-Based Case Report

Acta Medica Indonesiana
Background: Reperfusion serves as a mainstay therapy in almost all ischemic vascular diseases (IVD), but reperfusion may enhance cell damage after an ischemic period time.
Dono Antono, Ade Gautama, Nindya P.B.S Utami   +2 more
doaj   +2 more sources

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]

, 2012
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Members of the MCAO-SOP Group, Ulrich Dirnagl   +1 more
core   +2 more sources

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

Advanced Science, EarlyView.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen, Xiaoyan Jiang, Yuanhui Wang, Zhaobin Luo, Yu Zhang, Siwei Liu, Rui Huang, Dandan Zhang, Zhimin Tang, Yahan Ju, Shaohui Pan, Ni Ni, Wei Feng, Yu Chen, Ping Gu   +14 more
wiley   +1 more source