Results 91 to 100 of about 4,697,552 (378)

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Impacts of futile reperfusion and reperfusion injury in acute ischemic stroke

Brain Circulation
Acute ischemic stroke (AIS) remains to be a challenging cerebrovascular disease. The mainstay of AIS management is endovascular reperfusion therapy, including thrombectomy and thrombolysis.
Ahmed Elmadhoun, Hongrui Wang, Yuchuan Ding   +2 more
doaj   +1 more source

CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation [PDF]

, 2003
CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation.
Callard, R.E., Inwald, D.P., Klein, N.J., McDowall, A., Peters, M.J.   +4 more
core  

The meaning of different forms of structural myocardial injury, immune response and timing of infarct necrosis and cardiac repair [PDF]

, 2015
Although a decline in the all-cause and cardiac mortality rates following myocardial infarction (MI) during the past 3 decades has been reported, MI is a major cause of death and disability worldwide.
Bello, S, Fineschi, Vittorio, Neri, M, Pomara, C, Riezzo, I, Turillazzi, E   +5 more
core   +1 more source

Clinical Effects of Early Edaravone Use in Acute Ischemic Stroke Patients Treated by Endovascular Reperfusion Therapy

Stroke, 2019
Background and Purpose— Although several clinical studies suggested the beneficial effects of edaravone in acute ischemic stroke, most were performed under settings that differ from those in the current treatment strategy, which has dramatically changed ...
M. Enomoto, A. Endo, H. Yatsushige, K. Fushimi, Y. Otomo   +4 more
semanticscholar   +1 more source

Bioengineering Strategies for Treating Neointimal Hyperplasia in Peripheral Vasculature: Innovations and Challenges

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John, Caitlyn Dang, Nidhi Reddy, Calvin Chao, Karen J. Ho, Bin Jiang   +5 more
wiley   +1 more source

优化院内卒中救治体系对院内缺血性卒中再灌注治疗与预后的影响：单中心回顾性研究 Impact of Optimized In-hospital Stroke Emergency System on Reperfusion Therapy and Outcome of In-hospital Ischemic Stroke: A Single Center Retrospective Study

Zhongguo cuzhong zazhi, 2022
目的 基于北京协和医院自2021年以来构建的院内卒中救治体系，回顾性分析院内卒中救治体系对院内卒中患者再灌注治疗及预后的影响。 方法 连续纳入2013年3月-2022年1月因非卒中病因在北京协和医院住院期间新发缺血性卒中患者并进行临床资料的回顾性分析。收集人口学资料、血管危险因素、新发卒中临床及影像资料、急性期再灌注治疗、未接受再灌注治疗的原因、出院时神经功能结局。采用NIHSS评估急性期神经功能障碍程度（NIHSS 0～5分为轻型卒中，NIHSS 6～42分为中重度卒中 ...
洪月慧, 韩广淞, 吴娟娟, 沙宇惠, 付瀚辉, 周立新, 朱以诚, 倪俊
doaj   +1 more source

Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism. [PDF]

, 2014
Acute kidney injury (AKI) is a common complication of critical illness, and evidence is emerging that suggests AKI disrupts the function of other organs.
Abosaif, Andres-Hernando, Andres-Hernando, Barbara Philips, Boucher, Bougle, Brown, Chan, Chawla, Chung, Doi, Dowling, Dreisbach, Dreisbach, English, Fadillioglu, Gardiner, Gertz, Golab, Group, Gurley, Hassoun, Heinemeyer, Heinemeyer, Iain MacPhee, Izuwa, John Dixon, Karim, Katie Lane, Kirwan, Kirwan, Klein, Kramer, Krueger, Kunihara, Kunuzova, Lane, Lash, Leblanc, Lee, Lee, Lohr, Martyn, Mastorakos, Meier-Hellmann, Michaud, Michaud, Miyazawa, Muntane-Relat, Murakami, Naud, Naud, Nicholson, Nolin, Nolin, Okabe, Okabe, Okabe, Owen, O’Shaunessy, Park, Park, Philips, Power, Schneider, Serteser, Shi, Shibata, Smith, Soni, Spapen, Srinivas, Sun, Tanabe, Tian, Venkatesh, Wang, Whelton, Wilkinson, Wilson, Yamaguchi, Yoshitani, Yu   +82 more
core   +2 more sources

Reperfusion therapy in acute ischemic stroke: dawn of a new era?

BMC Neurology, 2018
Following the success of recent endovascular trials, endovascular therapy has emerged as an exciting addition to the arsenal of clinical management of patients with acute ischemic stroke (AIS).
S. Bhaskar, P. Stanwell, D. Cordato, J. Attia, C. Levi   +4 more
semanticscholar   +1 more source

Synthetic Bilirubin‐Based Nanomedicine Protects Against Renal Ischemia/Reperfusion Injury Through Antioxidant and Immune‐Modulating Activity

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
BX‐001N, a polyethylene glycol‐conjugated bilirubin 3α nanoparticle, is the first GMP‐grade, synthetic bilirubin‐based nanomedicine. It effectively attenuates acute renal injury, facilitates subacute renal recovery, and suppresses chronic fibrosis after renal ischemia/reperfusion injury via anti‐oxidant and immune‐modulating activity.
Ji‐Jing Yan, Hyunjin Kim, Bomin Kim, Honglin Piao, Joon Young Jang, Tae Kyeom Kang, Wook‐Bin Lee, Dohyeon Kim, Seunghyun Jo, Duckhyang Shin, Sharif MD Abuzar, Myung L. Kim, Jaeseok Yang, Sangyong Jon   +13 more
wiley   +1 more source