Results 341 to 350 of about 4,697,552 (378)

Cerium Oxide Nanoparticles Achieve Long‐Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation

Small Science, EarlyView.
The structure of synthesized cerium oxide nanoparticles (CeNPs) reveals antioxidative properties. CeNP reduces reactive oxygen species and shows good biocompatibility in muscle satellite cells. CeNP‐treated mice exhibit long‐acting anti‐sarcopenic effects through improved muscle mass and strength.
Wei‐Chih Lien, Yu‐Ling Yu, Ya‐Jyun Liang, Chia‐Yih Wang, Yang‐Chen Lin, Huei‐Cih Chang, Feng‐Huei Lin, Hui‐Min David Wang   +7 more
wiley   +1 more source

Nanozymes in Reactive Oxygen Species‐Dependent Diseases: From Design and Preclinical Studies to Clinical Translation Prospects

Small Structures, EarlyView.
Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou, Jingyu Yan, Chenying Cui, Yurong Xu, Kaifang Zhang, Meijun Du, Zhuowei Zhang, Xiuping Wu, Bing Li   +8 more
wiley   +1 more source

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

Aging Cell, EarlyView.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu, Qi Wang, Shuimiao Wang, Ying Liu, Qiqi Chen, Wanyun Qin, Xinna Liu, Xinqi Ye, Yexuan Jiao, Huiping Yuan, Zhengbo Shao   +10 more
wiley   +1 more source

Hemostatic activation during cardiopulmonary bypass with different aprotinin dosages in pediatric patients having cardiac operations [PDF]

, 1993
Baranky, A., Dietrich, W., Jochum, Marianne, Meisner, H, Mossinger, H., Richter, J. A., Spannagl, Michael, Wendt, P.   +7 more
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Neurocytoprotection advances in reperfusion therapy

S.S. Korsakov Journal of Neurology and Psychiatry
Acute stroke is the second leading cause of death and the third leading cause of disability in the world. Ischemic stroke (IS) the most common type of stroke. In acute cerebral ischemia, damage to the brain tissue is complex and includes blood-brain barrier (BBB) dysfunction, neuroinflammation, oxidative stress, activation of intracellular and ...
I.A. Shchukin, I.A. Koltsov, M.S. Fidler, A.P. Glukhareva   +3 more
openaire   +3 more sources

Drug‐Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia‐Reperfusion Therapy in Stroke

Advanced Functional Materials, 2023
Recanalization intervention is the primary recommended therapy for ischemic stroke, but the rapid progression of brain damage results in a very narrow time window for ischemia‐reperfusion therapy, which remains the biggest obstacle for ischemic stroke ...
Wenxiu He, Xiao-Yong Zhang, Xiang Gong, Kuankuan Luo, Xuening Mao, Enhao Lu, Yiting Chen, Rui Wang, Zhiwen Zhang, Jing Zhao, X. Sha   +10 more
semanticscholar   +1 more source

High Triglyceride Glucose Index Is Associated with Poor Outcomes in Ischemic Stroke Patients after Reperfusion Therapy

Cerebrovascular Diseases, 2021
Introduction: The triglyceride glucose index (TyG index) is a simple and reliable surrogate marker of insulin resistance (IR) that can predict functional outcomes and mortality after acute ischemic stroke (AIS).
Minwoo Lee, Chul-Ho Kim, Yerim Kim, M. Jang, Heejung Mo, Sang-Hwa Lee, Jae-Sung Lim, K. Yu, Byung‐Chul Lee, M. Oh   +9 more
semanticscholar   +1 more source

Reperfusion therapies and poststroke seizures

Epilepsy & Behavior, 2020
Seizures are not only a frequent complication of stroke but have been associated with an unfavorable functional and vital outcome of patients who have had stroke. Facing a new paradigm of acute standard stroke care, acute symptomatic seizures in this clinical setting deserve to be rethought.
Bentes, Carla, Brigo, Francesco, Zelano, Johan, Ferro, José   +3 more
openaire   +4 more sources

Cerebral collaterals in acute ischaemia: Implications for acute ischaemic stroke patients receiving reperfusion therapy

European Journal of Neuroscience, 2020
The cerebral collaterals play an important role in penumbral tissue sustenance after an acute ischaemic stroke. Recent studies have demonstrated the potential role of collaterals in the selection of acute ischaemic stroke patients eligible for ...
Abina Vishni Ravindran, M. Killingsworth, S. Bhaskar   +2 more
semanticscholar   +1 more source

Prognostic significance of uric acid change in acute ischemic stroke patients with reperfusion therapy

European Journal of Neurology, 2020
Uric acid (UA) is an important endogenous free radical scavenger that has been found to have a neuroprotective effect. However, there is uncertainty about the relationship between UA change and outcome in acute ischemic stroke (AIS) patients with ...
Changyi Wang, Ting Cui, Lu Wang, Qiange Zhu, Anmo Wang, Ye Yuan, Z. Hao, Bo Wu   +7 more
semanticscholar   +1 more source