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Therapy for early reperfusion after stroke [PDF]

Nature Clinical Practice Cardiovascular Medicine, 2006
Ischemic stroke is a leading cause of death and disability in the Western world. At present, intravenous administration of tissue plasminogen activator within 3 h of symptom onset is the only proven effective treatment to re-establish cerebral blood flow in the case of acute vessel occlusion.
Peter D. Schellinger, Eric Jüttler, Martin Köhrmann   +2 more
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Reperfusion therapy

Emergency Nurse, 2006
In this article Nick Castle explains that, with significant improvements being made to the emergency management of cardiac patients, emergency nurses should challenge and develop their clinical practice to ensure patients receive prompt and evidence based treatment.
openaire   +2 more sources

Reperfusion therapy for stroke

Australian and New Zealand Journal of Medicine, 1999
AbstractStroke is a heterogenous disease, but about 85% of strokes are as a result of cerebral ischaemia due to arterial occlusion. It seems logical to assume that, as in myocardial infarction, treatment designed to dissolve clots should be helpful.We now have a substantial amount of data on the use of aspirin, heparin and thrombolytic drugs in the ...
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Revascularization and reperfusion therapy

2008
This chapter focuses on revascularization and reperfusion therapy in the setting of ACS. Revascularization therapy is distinct from reperfusion therapy. The former takes place in non-ST-elevation or ST-elevation ACS, while reperfusion is employed only for ST-elevation myocardial infarction.
Deepak L. Bhatt, Anthony A. Bavry
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Reperfusion adjunctive therapy.

CHEST Journal, 1991
The beneficial effects of coronary thrombolytic therapy may be enhanced by certain adjunctive therapies. Some of these are of proven value, some appear to offer no benefit in spite of theoretical advantages, and some remain to be evaluated in clinical trials.
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Reperfusion Therapies for Acute Ischemic Stroke

Current Treatment Options in Neurology, 2010
Ischemic stroke is most often caused by an acute extracranial or intracranial thromboembolic lesion obstructing an artery. It has been demonstrated that recanalization is the most important modifiable predictor of a good clinical outcome. Reperfusion strategies focus on early reopening of the vessel to reestablish antegrade flow within the penumbra ...
Robert Mikulik, David Goldemund
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Collateral status reperfusion and outcomes after endovascular therapy: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) Registry

Journal of NeuroInterventional Surgery, 2021
Background Studies have suggested that collateral status modifies the effect of successful reperfusion on functional outcome after endovascular therapy (EVT).
M. Anadani, S. Finitsis, F. Clarençon, S. Richard, G. Marnat, R. Bourcier, I. Sibon, C. Dargazanli, C. Arquizan, R. Blanc, B. Lapergue, A. Consoli, F. Eugène, S. Vannier, L. Spelle, C. Denier, M. Boulanger, M. Gauberti, D. Liebeskind, A. D. de Havenon, S. Saleme, F. Macian, C. Rosso, O. Naggara, G. Turc, O. Ozkul-Wermester, Chrisanthi Papagiannaki, A. Viguier, C. Cognard, A. Le Bras, Sarah Evain, V. Wolff, R. Pop, S. Timsit, J. Gentric, F. Bourdain, L. Veunac, B. Maier, B. Gory   +38 more
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Reperfusion therapy in acute cerebrovascular syndrome

Current Opinion in Neurology, 2011
Modern reperfusion therapy in acute ischemic stroke therapy is based on an 'as fast as possible' recanalization approach to obtain favorable clinical outcomes. However, arterial recanalization may be achieved without favorable clinical outcome, raising the question of the target population to be treated.
Pierre Amarenco, Mikael Mazighi
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Pharmacological therapy for myocardial reperfusion injury

Current Opinion in Pharmacology, 2004
In the ischemic myocardium, reperfusion is necessary for the salvage of cells and cardiac function. However, reperfusion itself causes 'reperfusion injury', leading to the damage of myocardial cells. This is reduced by several interventions, as measured by the limitation of infarct size or reduction of arrhythmias.
Chakib M. Ayoub, Antoine Abchee, George V. Moukarbel   +2 more
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Reperfusion Therapies in Acute Ischemic Stroke

Recent Patents on CNS Drug Discovery, 2015
Acute Ischemic stroke (IS) remains a leading cause of mortality and long-term disability. Owing to the time-constraints, only a fraction of acute IS patients receive the established and approved thrombolytic therapy and a sizeable proportion of acute IS stroke survivors remain permanently disabled.
Vivek Sharma, Wan Yee, Leonard L.L. Yeo, Benjamin Yong-Qiang Tan, Amit Kulkarni   +4 more
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