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Therapy for early reperfusion after stroke [PDF]
Ischemic stroke is a leading cause of death and disability in the Western world. At present, intravenous administration of tissue plasminogen activator within 3 h of symptom onset is the only proven effective treatment to re-establish cerebral blood flow in the case of acute vessel occlusion.
Peter D. Schellinger+2 more
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Emergency Nurse, 2006
In this article Nick Castle explains that, with significant improvements being made to the emergency management of cardiac patients, emergency nurses should challenge and develop their clinical practice to ensure patients receive prompt and evidence based treatment.
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In this article Nick Castle explains that, with significant improvements being made to the emergency management of cardiac patients, emergency nurses should challenge and develop their clinical practice to ensure patients receive prompt and evidence based treatment.
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Reperfusion therapy for stroke
Australian and New Zealand Journal of Medicine, 1999AbstractStroke is a heterogenous disease, but about 85% of strokes are as a result of cerebral ischaemia due to arterial occlusion. It seems logical to assume that, as in myocardial infarction, treatment designed to dissolve clots should be helpful.We now have a substantial amount of data on the use of aspirin, heparin and thrombolytic drugs in the ...
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Revascularization and reperfusion therapy
2008This chapter focuses on revascularization and reperfusion therapy in the setting of ACS. Revascularization therapy is distinct from reperfusion therapy. The former takes place in non-ST-elevation or ST-elevation ACS, while reperfusion is employed only for ST-elevation myocardial infarction.
Deepak L. Bhatt, Anthony A. Bavry
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Reperfusion adjunctive therapy.
CHEST Journal, 1991The beneficial effects of coronary thrombolytic therapy may be enhanced by certain adjunctive therapies. Some of these are of proven value, some appear to offer no benefit in spite of theoretical advantages, and some remain to be evaluated in clinical trials.
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Reperfusion Therapies for Acute Ischemic Stroke
Current Treatment Options in Neurology, 2010Ischemic stroke is most often caused by an acute extracranial or intracranial thromboembolic lesion obstructing an artery. It has been demonstrated that recanalization is the most important modifiable predictor of a good clinical outcome. Reperfusion strategies focus on early reopening of the vessel to reestablish antegrade flow within the penumbra ...
Robert Mikulik, David Goldemund
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Journal of NeuroInterventional Surgery, 2021
Background Studies have suggested that collateral status modifies the effect of successful reperfusion on functional outcome after endovascular therapy (EVT).
M. Anadani+38 more
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Background Studies have suggested that collateral status modifies the effect of successful reperfusion on functional outcome after endovascular therapy (EVT).
M. Anadani+38 more
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Reperfusion therapy in acute cerebrovascular syndrome
Current Opinion in Neurology, 2011Modern reperfusion therapy in acute ischemic stroke therapy is based on an 'as fast as possible' recanalization approach to obtain favorable clinical outcomes. However, arterial recanalization may be achieved without favorable clinical outcome, raising the question of the target population to be treated.
Pierre Amarenco, Mikael Mazighi
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Pharmacological therapy for myocardial reperfusion injury
Current Opinion in Pharmacology, 2004In the ischemic myocardium, reperfusion is necessary for the salvage of cells and cardiac function. However, reperfusion itself causes 'reperfusion injury', leading to the damage of myocardial cells. This is reduced by several interventions, as measured by the limitation of infarct size or reduction of arrhythmias.
Chakib M. Ayoub+2 more
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Reperfusion Therapies in Acute Ischemic Stroke
Recent Patents on CNS Drug Discovery, 2015Acute Ischemic stroke (IS) remains a leading cause of mortality and long-term disability. Owing to the time-constraints, only a fraction of acute IS patients receive the established and approved thrombolytic therapy and a sizeable proportion of acute IS stroke survivors remain permanently disabled.
Vivek Sharma+4 more
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