Results 51 to 60 of about 181,215 (307)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Peculiarities and recommendations of acute stroke treatment during the COVID-19 pandemic

Neurologijos seminarai, 2020
The global COVID-19 pandemic poses enormous challenges to healthcare systems and has a major impact on the treatment and care of stroke patients. In the article, the authors review the issues of acute stroke diagnosis, treatment, and prevention during ...
A. Vilionskis , R. Masiliūnas , A. Ekkert , D. Jatužis   +3 more
doaj   +1 more source

Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy [PDF]

, 2010
Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction ...
Babu, Suresh, Mungli, Prakash, Shetty, Jeevan K   +2 more
core   +1 more source

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]

, 2009
The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA   +2 more
core   +1 more source

Inequalities in reperfusion therapy for STEMI [PDF]

European Heart Journal - Quality of Care and Clinical Outcomes, 2016
This editorial refers to “Reperfusion therapy for ST-elevation acute myocardial infarction in Eastern Europe: the ISACS-TC registry”, by E. Cenko et al ., on page 45. Reperfusion therapy, either by intravenous fibrinolysis or percutaneous coronary intervention (PCI), is the cornerstone of the management of ST-elevation myocardial infarction (STEMI).1
openaire   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy

Journal of Stroke and Cerebrovascular Diseases
This article provides perspectives on the use of Cerebrolysin as an adjunct treatment to reperfusion therapy in acute ischemic stroke (AIS). In the evolving landscape of AIS reperfusion therapy, we hypothesize that adjunctive cerebroprotective therapy ...
Marc Ribó, Jacek Staszewski, Steven R. Zeiler, Sławomir Michalak, Ahmed El Bassiouny, Fernando Gongora-Rivera, Zdravka Poljakovic, Dina R Khasanova, Mikhail N Kalinin, Aurauma Chutinet, Roni Eichel, Klaudyna Kojder, Marissa Ong, Marina Roje Bedeković, Chien-Hung Chang, Minwoo Lee, Peter Quitasol, Alexander Tsiskaridse, Natan M Bornstein   +18 more
doaj   +1 more source

Metabolic and cardiac adaptation to chronic pharmacologic blockade of facilitative glucose transport in murine dilated cardiomyopathy and myocardial ischemia [PDF]

, 2018
GLUT transgenic and knockout mice have provided valuable insight into the role of facilitative glucose transporters (GLUTs) in cardiovascular and metabolic disease, but compensatory physiological changes can hinder interpretation of these models.
Heitmeier, Monique R., Hresko, Richard C., Hruz, Paul W., Jay, Patrick Y., Kovacs, Attila, Payne, Maria A., Weinheimer, Carla   +6 more
core   +2 more sources

Current issues in reperfusion therapy

The American Journal of Cardiology, 1998
With the establishment of thrombosis as the cause of myocardial infarction, the pivotal role of thrombolytics and primary angioplasty has evolved. Large randomized trials with innovative methodologies have examined the role of these reperfusion therapies in the management of acute coronary syndromes. Intravenous thrombolytic therapy decreases mortality
openaire   +2 more sources

Adjunctive therapy after reperfusion therapy in acute myocardial infarction [PDF]

Clinical Cardiology, 1998
AbstractThe current era has witnessed dramatic improvement in the treatment of acute myocardial infarction, due in large part to the more widespread use of thrombolytic therapy aimed at quickly restoring perfusion in the infarct‐related artery. This review addresses the role of adjunctive pharmacologic therapy in the thrombolytic era, recognizing that ...
D L, Dries, A J, Solomon, B J, Gersh
openaire   +2 more sources