Results 261 to 270 of about 705,796 (337)

Lupeol‐Loaded Liposomes: Triple‐Negative Breast Cancer (TNBC) Cytotoxicity and In Vivo Toxicological Evaluation

Chemistry &Biodiversity, EarlyView.
ABSTRACT Lupeol is a natural product commonly found in many vegetables and fruits in significant quantities. Previous studies have demonstrated the relevant activity of lupeol against various tumor cell lines, suggesting that the natural product could be a promising agent for cancer treatment.
Daniel Crístian Ferreira Soares, Daniel Bragança Viana, André Luis Branco de Barros, Sued Eustáquio Mendes Miranda, Daniela Sachs, Eduardo Henrique Martins Nunes, Eryvaldo Sócrates Tabosa do Egito   +6 more
wiley   +1 more source

KDDC: a new framework that integrates kmers, dataset filtering, dimension reduction and classification algorithms to achieve immune cell heterogeneity classification. [PDF]

Front Immunol
Zhang N, Zhao S, Wu R, Luo X, Yang M, Chang Z, Xu J.   +6 more
europepmc   +1 more source

Thymidine Phosphorylase Inhibitory Potential and Molecular Docking Studies of Secondary Metabolites Isolated From Fernandoa adenophylla (Wall. ex G. Don) Steenis

Chemistry &Biodiversity, EarlyView.
ABSTRACT This study investigates the potential of Fernandoa adenophylla, a South American plant, as a reservoir of compounds with thymidine phosphorylase (TP) inhibitory activity. Through a comprehensive approach combining in vitro assays and molecular docking analysis, we isolated and characterized bioactive compounds from F.
Abdur Rauf, Majid Khan, Umer Rashid, Anees Saeed, Zafar Ali Shah, Zubair Ahmad, Abdulhakeem S. Alamri, Walaa F. Alsanie, Imtiaz Khan, Humaira Hussain, Majid Alhomrani, Marcello Iriti   +11 more
wiley   +1 more source

Distinct Omicron longitudinal memory T cell profile and T cell receptor repertoire associated with COVID-19 hospitalisation. [PDF]

Front Immunol
Markey G, McLaughlin J, McDaid D, Lynch SM, English A, Alexander HD, Kelly M, Bhavsar M, McGilligan V, Zhang SD, Murray EK, Rai TS, Walsh C, Bjourson AJ, Shukla P, Gibson DS.   +15 more
europepmc   +1 more source

Characterization of the Cubamyces Menziesii Terpenome

ChemBioChem, EarlyView.
The genome of Cubamyces menziesii reveals 18 putative sesquiterpene cyclase genes. These genes are cloned and expressed in Escherichia coli, yielding 10 active enzymes. Using farnesyl diphosphate as substrate, the enzymes are analyzed, and the products characterized after bioconversion, uncovering diverse sesquiterpene structures. This study highlights
Létitia Leydet, Julie Couillaud, Agnès Amouric, Elise Courvoisier‐Dezord, Carole Avesque, Thierry Giardina, Mireille Attolini, Pierre Rousselot‐Pailley, Katia Duquesne, Marie‐Noelle Rosso, Gilles Iacazio   +10 more
wiley   +1 more source

Acupoint Injection Combined with BCG-PSN and Thymosin Enteric-Coated Tablets Improve China Han Psoriasis Vulgaris by Regulating T Cell Subsets. [PDF]

Psoriasis (Auckl)
Li J, Zhao X, Pan H, Duan Y, Li W, Zhao Y, Yao L, Zhang K.   +7 more
europepmc   +1 more source

Poly(ethylene Glycol)‐Based Peptidomimetics (Pegtides) of Antimicrobial Peptides

ChemBioChem, EarlyView.
Polyethylene glycol (PEG) is commonly used to improve the pharmacokinetics and pharmacodynamics of therapeutic candidates by conjugation. Here PEG is exploited for peptidomimetic conversion of antimicrobial peptides (AMPs), as candidate antibacterial agents, by replacing their polyamide backbone. The pegtides obtained thereby can be readily synthesized
Conor Shine, John R. F. B. Connolly, Robert D. Murphy, Hazel Lafferty, Abdalmalek Alfnikh, Ned P. Buijs, Hawraa Shahrour, Nathaniel I. Martin, Eoghan O'Neill, George Amarandei, Jimmy Muldoon, Marc Maresca, Deirdre Fitzgerald‐Hughes, Marc Devocelle   +13 more
wiley   +1 more source

Characterization of the Neoantigen Profile in a Tumor Mutation Burden-high Melanoma Patient With Multiple Metastases. [PDF]

Cancer Genomics Proteomics
Yoshikawa S, Maeda C, Iizuka A, Ikeya T, Yamashita K, Ashizawa T, Kanematsu A, Miyata H, Kikuchi Y, Urakami K, Ohshima K, Nagashima T, Yamaguchi K, Kiyohara Y, Akiyama Y.   +14 more
europepmc   +1 more source

In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins

ChemBioChem, Accepted Article.
Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska, Jan Hendrik Illies, T. Moritz Weber   +2 more
wiley   +1 more source

A comprehensive evaluation of diversity measures for TCR repertoire profiling. [PDF]

BMC Biol
Mika J, Polanska A, Blenman KR, Pusztai L, Polanska J, Candéias S, Marczyk M.   +6 more
europepmc   +1 more source