Results 261 to 270 of about 889,250 (400)

SatTCR: a pipeline for performing saturation analysis of the T cell receptor repertoire and a case study of a healthy canine. [PDF]

MethodsX
Welch Schwartz R, Zuleger CL, Newton MA, Vail DM, Albertini MR, Ong IM.   +5 more
europepmc   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Predictive potential of patient-specific immunological characteristics in solid cancers: circulating monocytes, myeloid-derived suppressor cells, T cells, and the T-cell receptor repertoire. [PDF]

ESMO Open
Zierfuss C, Niederdorfer B, Fendl B, Syböck K, Schedl J, Kohl L, Heller G, Tomasich E, Berger JM, Sunder-Plassmann V, Kleinberger M, Gottmann L, Korpan M, Starzer AM, Solano Henao I, Fürst J, Wolfsberg J, Grohmannova M, Dobrovits N, Ay C, Vladic N, Furtner J, Preusser M, Berghoff AS.   +23 more
europepmc   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

TCR representation learning with protein language models: a comprehensive review. [PDF]

Int Immunol
Kinoshita K, Kobayashi TJ.
europepmc   +1 more source

100Vβ repertoire analysis of tissue infiltrating CD8+ Tcells responding to minor histocompatibility antigens involved in graft-versus-host disease

, 2003
Thea M. Friedman, Delivette Castor, Stephen C. Jones, Robert Korngold   +3 more
openalex   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Resistance potential of the HLA-A2-restricted immunodominant SARS-CoV-2-specific CD8⁺ T cell receptor repertoire to antigenic drift. [PDF]

Nat Commun
Malone MJ, Huang C, Zhang Y, Qi Y, Williams L, Su LF, Lou J, Jiang N.   +7 more
europepmc   +1 more source

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma. [PDF]

J Immunother Cancer
Herold N, Bochem J, Leyens J, Wingerter S, Forchhammer S, Spreuer J, Deseke M, Yurttas C, Nocerino P, Antunes Dos Reis R, Amaral T, Wagner NB, Thiel K, Soffel D, Bieber K, Terheyden P, Wesch D, Oberg HH, Sebens S, Claassen M, Königsrainer A, Garbe C, Pawelec G, Meier F, Löffler MW, Weide B, Prinz I, Ravens S, Kordasti S, Eigentler T, Wistuba-Hamprecht K.   +30 more
europepmc   +1 more source