Results 31 to 40 of about 24,142 (282)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Prairie Repertory Theatre 1976
, 1976 Poster, clippings, advertisements and photographs from the 1976 Prairie Repertory Theatre season.
core +1 more source
Teatro nigerianoy temas cruciales.Jos Repertory Theatre
Periférica, 2019 La compañía Jos Repertory Theatre fue fundada en noviembre de 1997 por el Dr. PatrickJude Oteh, pero la implementación completa del programa comenzó en 2000 como una organización de teatro independiente sin ánimo de lucro que busca utilizar el teatro ...
María Aránzazu Fernández Giles
doaj +3 more sources
Управление культурой, 2022 The article discusses about the different models of organizing theatrical business: the system of the repertory theater as the most common in Russia which corresponds to a hierarchical form of management and the model of a producer or project theater ...
Andrey G. Shishkin
doaj
Studia Universitatis Babeş-Bolyai. Musica, 2019 The funeral repertory represents a privileged field in the history of music, which reflects the deepest expression of each composer or era. Funeral music was generally approached at the end of the works or at mature moments in composing art.
Petruța-Maria COROIU
doaj +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source