Results 31 to 40 of about 21,767 (283)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Prairie Repertory Theatre 1975 Season
, 1975 Reviews,advertisements and other material from the 1975 of the Prairie Repertory Theatre season.
core +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Teatro nigerianoy temas cruciales.Jos Repertory Theatre
Periférica, 2019 La compañía Jos Repertory Theatre fue fundada en noviembre de 1997 por el Dr. PatrickJude Oteh, pero la implementación completa del programa comenzó en 2000 como una organización de teatro independiente sin ánimo de lucro que busca utilizar el teatro ...
María Aránzazu Fernández Giles
doaj +3 more sources
Studia Universitatis Babeş-Bolyai. Musica, 2019 The funeral repertory represents a privileged field in the history of music, which reflects the deepest expression of each composer or era. Funeral music was generally approached at the end of the works or at mature moments in composing art.
Petruța-Maria COROIU
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Prairie Repertory Theatre 1976
, 1976 Programs and photographs from the 1976 Prairie Repertory Theatre season.
core +1 more source
Réseaux transnationaux d’artistes et relocalisation du répertoire « afro-cubain » dans le Veracruz
Revue Européenne des Migrations Internationales, 2009 The afro Cuban musical and chorographical repertory is considered to be a legitimate and valuable contribution to Cuba’s national cultural identity. It conveys to the non Cuban public, through professional musicians and dancers who are also practitioners
Kali Argyriadis
doaj +1 more source