Results 151 to 160 of about 675,124 (207)

Beyond Bulk: Cell‐Type‐Resolved Epigenomics as the Path Forward in Alzheimer's Disease Research

European Journal of Neuroscience, Volume 64, Issue 5, September 2026.
Alzheimer's disease affects multiple brain cell types through distinct epigenetic mechanisms. Although bulk analyses obscure these cell‐type‐specific changes, cell sorting and single‐cell epitranscriptomic approaches provide the resolution needed to uncover and understand epigenetic dysregulation at the cell‐type level in AD.
Lucía Cañizares‐Moscato, Jose Ruiz‐Iglesias, Javier Isoler‐Alcaraz, Ernest Palomer   +3 more
wiley   +1 more source

Reinforcement learning for proposing smoking cessation activities that build competencies: Combining two worldviews in a virtual coach. [PDF]

BMC Med Inform Decis Mak
Albers N, Neerincx MA, Brinkman WP.
europepmc   +1 more source

Unpacking Resilience in Public Administration: Insights From a Meta‐Narrative Review

Public Administration Review, Volume 86, Issue 5, Page 1235-1254, September/October 2026.
ABSTRACT Increasing environmental complexity and uncertainty have made organizational resilience a key concern in public administration. Yet its inherent ambiguity calls for a systematic examination of its conceptualizations, operationalizations, and applications. This meta‐narrative review synthesizes 49 studies, advancing the discourse by identifying
Jixiang Li, Shui‐Yan Tang, Bo Wen
wiley   +1 more source

Construing motherhood across generations in Taiwan's social transition: associations with depression and somatic symptoms. [PDF]

Front Psychol
Lin Y.
europepmc   +1 more source

The pathogenic effector PHYL1JWB interacts with ZjCURT1A to mediate jujube witches' broom‐induced photosynthesis impairment of jujube trees

The Plant Journal, Volume 127, Issue 5, September 2026.
SUMMARY Photosynthesis impairment and the accompanying leaf yellowing represent a prominent and physiologically critical symptom of phytoplasma infection. However, the underlying molecular mechanisms remain poorly understood. In this study, we identified the Jujube Witches' Broom pathogenic effector PHYL1JWB, which was previously reported to induce ...
Fangfang Huang, Changfeng Ai, Chong Yang, Jie Feng, Meng Yang, Li Dai, Chaoling Xue, Hongtai Li, Jiaxue Cui, Xiangjie Qu, Jin Zhao, Mengjun Liu, Xuan Zhao, Zhiguo Liu   +13 more
wiley   +1 more source

Correction: Osteo-inductive potential of homoeopathy potencies of Asafoetida on multipotent mesenchymal stem cells in vitro. [PDF]

3 Biotech
Moharana SS, Mallick S, Pinto JR, P SS, Bose B.   +4 more
europepmc   +1 more source

Kinetic Compatibility as a Predictor of PTP1B Inhibitor Combination Outcomes: An Integrated Experimental and Computational Study

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Combining PTP1B inhibitors of distinct kinetic mechanisms determines their pharmacological outcome. Integrating enzyme kinetics, docking, molecular dynamics, and membrane‐permeability simulations, we show that mechanistically compatible pairs (competitive + competitive; uncompetitive + mixed) yield additivity, whereas competitive + uncompetitive ...
Jonathan Trapala, Laura I. Álvarez‐Añorve, Nathaly Vasquez‐Martínez, Erika Chavira‐Suárez, Luz Vásquez‐Bochm, Deyamira Matuz‐Mares, Francisco Cortés‐Benítez, Martin González‐Andrade   +7 more
wiley   +1 more source

Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Ligand‐based virtual screening of over five million compounds identifies a thienopyrimidinone hit as a novel allosteric nSMase2 modulator. Structure‐guided optimisation improves inhibitory potency and delivers derivatives with antiviral activity against West Nile virus, expanding the chemical space of nSMase2 inhibitors and supporting host‐directed ...
Hadrián Álvarez‐Fernández, Patricia Mingo‐Casas, Ana‐Belén Blázquez, Flavia Caridi, Miguel A. Martín‐Acebes, María‐Jesús Pérez‐Pérez, Eva‐María Priego   +6 more
wiley   +1 more source

Editorial: Exploring human-autonomous interactions: agency, awareness, and ethical implications. [PDF]

Front Psychol
Lo Bue S, Prével A, Salatino A.
europepmc   +1 more source