Results 51 to 60 of about 14,626 (254)

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Pedestrian Amenity: On Street Survey Design [PDF]

, 1987
Any new road, road improvement or traffic management scheme could affect pedestrian journeys in its locality or elsewhere. Some journeys may be affected directly, with severance caused where the new road or road improvement cuts across a pedestrian ...
Hopkinson, P.G., May, A.D., Turvey, I.G.
core  

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Repertory Grid Technique and Honey’s Content Analysis: gathering and processing qualitative data [PDF]

RAUSP Management Journal
Purpose – This study aims to demonstrate a rigorous approach to applying the Repertory Grid Technique (RGT) and Honey’s Content Analysis (HCA) to obtain and process qualitative data through structured interviews.
Marina Bastos Carvalhais Barroso, Ricardo Silveira Martins, Jonathan Simões Freitas   +2 more
doaj   +1 more source

Self-esteem, anxiety and assertiveness : a theoretical and empirical approach to the effects of assertion training : submitted as part of the requirements for the degree of Master of Arts (Clinical Psychology) [PDF]

, 1980
This study was conducted as a tentative investigation of the effect of Assertiveness Training on "normal to pre-clinical" outpatients attending a small psychological clinic.
Smee, Juliana Majella
core  

Exploring the perceptions of staff towards children and young people living in community-based children's homes [PDF]

, 2003
This article examines the perceptions of staff working in community-based children's homes. Data from interviews with staff, using the repertory grid technique, are analysed and presented in the form of a case study.
Chakrabarti, Mono, Heron, Gavin, University of Strathclyde   +2 more
core   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Cognitive representations of disability behaviours in people with mobility limitations : consistency with theoretical constructs [PDF]

, 2008
Disability is conceptualised as behaviour by psychological theory and as a result of bodily impairment by medical models. However, how people with disabilities conceptualise those disabilities is unclear.
Bandura A, Bandura A, Bellamy N, Diane Dixon, Ewart C K, Fransella F, Johnston M, Johnston M, Kelly G A, Leventhal H, Marie Johnston, Martin J, Patrick D L, Pollard B, Toshima M T, Ware J E, World Health Organization, World Health Organization   +17 more
core   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

The role of wealth in the experience of quality of life of the semi–affluent investor

SA Journal of Industrial Psychology, 2006
In an attempt to assist semi-affluent investors’ best use their wealth to improve their lives, this study explores the role of wealth in the experience of quality of life.
L M Meyer, J S Uys
doaj   +1 more source