Results 161 to 170 of about 22,534,100 (211)

The pathogenic effector PHYL1JWB interacts with ZjCURT1A to mediate jujube witches' broom‐induced photosynthesis impairment of jujube trees

open access: yesThe Plant Journal, Volume 127, Issue 5, September 2026.
SUMMARY Photosynthesis impairment and the accompanying leaf yellowing represent a prominent and physiologically critical symptom of phytoplasma infection. However, the underlying molecular mechanisms remain poorly understood. In this study, we identified the Jujube Witches' Broom pathogenic effector PHYL1JWB, which was previously reported to induce ...
Fangfang Huang   +13 more
wiley   +1 more source

Kinetic Compatibility as a Predictor of PTP1B Inhibitor Combination Outcomes: An Integrated Experimental and Computational Study

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
Combining PTP1B inhibitors of distinct kinetic mechanisms determines their pharmacological outcome. Integrating enzyme kinetics, docking, molecular dynamics, and membrane‐permeability simulations, we show that mechanistically compatible pairs (competitive + competitive; uncompetitive + mixed) yield additivity, whereas competitive + uncompetitive ...
Jonathan Trapala   +7 more
wiley   +1 more source

Multicenter study on the versatility and adoption of AI-driven automated radiotherapy planning across cancer types. [PDF]

open access: yesNat Commun
Yu L   +11 more
europepmc   +1 more source

Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
Ligand‐based virtual screening of over five million compounds identifies a thienopyrimidinone hit as a novel allosteric nSMase2 modulator. Structure‐guided optimisation improves inhibitory potency and delivers derivatives with antiviral activity against West Nile virus, expanding the chemical space of nSMase2 inhibitors and supporting host‐directed ...
Hadrián Álvarez‐Fernández   +6 more
wiley   +1 more source

Creative Work as Seen Through the ATHENA Competency Model. [PDF]

open access: yesBehav Sci (Basel)
Lamri J   +3 more
europepmc   +1 more source

Virtual reality in psychological interventions for mood disorders: a scoping review. [PDF]

open access: yesBMC Psychiatry
Wang Y   +6 more
europepmc   +1 more source

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