Results 51 to 60 of about 10,116 (248)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Giving the customer a voice: A study of market research methods and their perceived effectiveness in NPD [PDF]

, 2013
There is a widely held view that a lack of, “…customer understanding,” is one of the main reasons for product failure (Eliashberg et al., 1997, p. 219). This is despite the fact that new product development (NPD) is a crucial business process for many
Goffin, Keith, Michea, Adela, van der Hoven, Christopher, Varnes, Claus   +3 more
core  

Towards a classification framework for social machines [PDF]

, 2013
The state of the art in human interaction with computational systems blurs the line between computations performed by machine logic and algorithms, and those that result from input by humans, arising from their own psychological processes and life ...
Daniel Alex, Elena Simperl, Er Smith, Max Van Kleek, Nigel Shadbolt, Wendy Hall, Yang Yang   +6 more
core   +2 more sources

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Identifying and Ranking Factors Affecting the Realization of Sustainable Production with a Shift from Industrial to Ecological Production(Case Study: Private Industrial Manufacturing Companies in Semnan) [PDF]

پژوهش‌های مدیریت عمومی, 2017
In general, sustainable progress is a landscape that simultaneously aims for social, economic, and environmental subjects, in the process of progress. In this course, production management and manufacturers are involved in sustainability more than ever. 
Mohammad Ali Shariat, Soleyman Iranzadeh, Alireza Bafandeh Zendeh   +2 more
doaj   +1 more source

Understanding the use value dimensions of outsourced maintenance services [PDF]

, 2010
Surviving in long-term outsourced maintenance contracts in current financial situation necessitates better understanding of what customers attribute as value and its dimensions.
Lockett, Helen, Martinez, Veronica, Raja, Jawwad, Toossi, Amir   +3 more
core  

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

When words fail us: An integrative review of innovative elicitation techniques for qualitative interviews. [PDF]

Med Educ
Abstract Introduction Interviews are central to many qualitative studies in health professions education (HPE). However, researchers often struggle to elicit rich data and engage diverse participants who may find this strategy exclusionary. Elicitation techniques are strategies tailored to address these challenges, enhancing oral conversations through ...
Kahlke R, Maggio LA, Lee MC, Cristancho S, LaDonna K, Abdallah Z, Khehra A, Kshatri K, Horsley T, Varpio L.   +9 more
europepmc   +2 more sources

Pedestrian Amenity: On Street Survey Design [PDF]

, 1987
Any new road, road improvement or traffic management scheme could affect pedestrian journeys in its locality or elsewhere. Some journeys may be affected directly, with severance caused where the new road or road improvement cuts across a pedestrian ...
Hopkinson, P.G., May, A.D., Turvey, I.G.
core  

A novel use of honey's aggregation approach to the analysis of repertory grids [PDF]

, 2018
This paper examines and appraises a novel approach to generating shared group constructs through aggregative analysis: the application of Honey’s aggregation procedure to repertory grid technique (RGT) data.
Almuth McDowall, Arnold J., Campbell J. P., Campbell J. P., Curtis A., Céline Rojon, Dubin R., Green B., Hill R. A., Jankowicz D, Kelly G. A., Kelly G. A., Mark N. K. Saunders, Patton M. Q., Sackett P. R., Simpson B., Slater P.   +16 more
core   +3 more sources