Results 61 to 70 of about 10,116 (248)

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

The Construal of Midwives by Pregnant Women with a Body Mass Index Greater Than or Equal to 30 kg/m2 (BMI ≥ 30 kg/m2): A Repertory Grid Study [PDF]

, 2017
Objective To explore the construal of midwives by pregnant women with a body mass index greater than 30 kg/m2 (BMI ≥ 30 kg/m2). Method Ten pregnant women with a BMI ≥ 30 kg/m2 were recruited from antenatal clinics at a maternity hospital in the ...
Bjorklund, Blundell, Bulik, Cameron, Campbell, Faccio, Fransella, Fudge, Furber, Furness, Gaines, Goold, Hagans, Heslehurst, Heslehurst, Heslehurst, Higgins, Jankowicz, Jorm, Kelly, Klaczynski, Marleau, Marleau, Mold, Mulherin, Neimayer, Phelan, Puhl, Puhl, Sebire, Shin, Smith, Smith, Smith, Smith, Thomas, Vermeire, Weisman   +37 more
core   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Exploring Users’ Mental Models for Anthropomorphized Voice Assistants through Psychological Approaches

Applied Sciences, 2021
Various perspectives are being studied to increase the usability and persistence of voice assistants (VA) as the use is rapidly expanding to various domains. Particularly, many studies note that users personify VA.
Dasom Park, Kiechan Namkung
doaj   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Exploring consumer product construct systems with the repertory grid technique

Qualitative Market Research: An International Journal, 2000
Examines some of the applications of repertory grid technique and theory to qualitative market research. In particular, it shows how together they can be used to explore five basic components of the network of subjective meanings that consumers attach to their consumption experiences, what are termed here consumers’ product construct systems (PCSs ...
Marsden, D., Littler, Dale
openaire   +2 more sources

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

Balancing dual roles in self-employed women: An exploratory study

SA Journal of Industrial Psychology, 2009
This study is aimed at exploring how self-employed women cope in balancing their dual roles as mothers and executives. Through the elicitation of constructs by making use of Kelly’s repertory grid technique, the personal construct system of five self ...
Kirsty-Lee McLellan, Koos Uys
doaj   +1 more source

Utilising the repertory grid technique in visual prosthetic design : promoting a user-centred approach [PDF]

, 2016
This paper proposes a new User-Centred data-collection methodology based on the 9 Repertory Grid Technique (RGT) for the aesthetic design of below-knee prostheses.
Buis, Arjan, McFadyen, Angus, Sansoni, Stefania, Wodehouse, Andrew   +3 more
core   +1 more source

gnSPADE: Incorporating Gene Network Structures Enhances Reference‐Free Deconvolution in Spatial Transcriptomics

Advanced Intelligent Systems, EarlyView.
gnSPADE integrates gene‐network structures into a probabilistic topic modeling framework to achieve reference‐free cell‐type deconvolution in spatial transcriptomics. By embedding gene connectivity within the generative process, gnSPADE enhances biological interpretability and accuracy across simulated and real datasets, revealing spatial organization ...
Aoqi Xie, Yuehua Cui
wiley   +1 more source