Results 111 to 120 of about 1,239,643 (278)
Generation of optical frequency combs with a CaF2 resonator [PDF]
, 2009 We demonstrate optical frequency combs using the fluorite whispering gallery mode resonator as a nonlinear Kerr medium. Two regimes of generation are observed, giving the record low repetition rate of 13 GHz, equal to the cavity's free spectral range ...
Grudinin, Ivan S., Maleki, Lute, Yu, Nan
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Søren Kierkegaard’s Repetition. Existence in Motion [PDF]
, 2014 This article tries to make sense of the concept of repetition in Søren Kierkegaard’s works. According to Kierkegaard repetition is a temporal movement of existence. What is repetition and what is its meaning for human existence?
Bârliba, Ionuț Alexandru
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
De la palabra al género: un itinerario
Filología, 2014 La obra de Ana María Barrenechea se caracteriza por una atención a los modos de leer. Aquí se propone, más allá de las adhesiones disciplinares y a partir de unas determinadas experiencias de trabajo (es decir: de vida comunitaria) una relectura de la ...
Daniel Link
doaj
Danger and Disability: The Female Body of Miniature in Neo-Victorian Fiction [PDF]
, 2018 Neo-Victorian reimaginations of the freak simultanously repeat and reject the binaries of normalcy and deviance to criticise the exploitative and objectifying conventions of nineteenth-century enfreakment practices.
Pettersson, Lin Elinor
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Note sulla catastrofe del senso: Bernhard, Gargani, Derrida [PDF]
Kaiak, 2016 This essay examines some aspects of Thomas Bernhard’s works concerning the catastrophe of meaning, by the thought of two philosophers: Aldo Giorgio Gargani and Jacques Derrida. It is possible to escape from the ordinary procedures of criticizing the
Igor Pelgreffi
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