Results 91 to 100 of about 300,274 (266)
Note sulla catastrofe del senso: Bernhard, Gargani, Derrida [PDF]
Kaiak, 2016 This essay examines some aspects of Thomas Bernhard’s works concerning the catastrophe of meaning, by the thought of two philosophers: Aldo Giorgio Gargani and Jacques Derrida. It is possible to escape from the ordinary procedures of criticizing the
Igor Pelgreffi
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Hryhorii Skovoroda's Aphoristics: Structural, Semantic and Stylistic Aspects
Вісник Харківського національного університету імені В. Н. Каразіна. Серія Філологія. Vìsnik Harkìvsʹkogo nacìonalʹnogo unìversitetu ìmenì V.N. Karazìna. Serìâ Fìlologìâ.Consideration of the aphorism of the famous thinker in terms of syntactic construction of the expressed thought and creation of various stylistic techniques in this plane to enhance it is relevant.
Yuliya Kalashnyk
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Doppelgänger Architecture : The Dialectical Pair as a Representational System
Cuadernos de Proyectos Arquitectónicos, 2018 This paper proposes to examine the role of the doppelgänger as a representational system in architecture. In this field, the figure of the double shows particular nuances derived from its spatial and material condition.
Luz Carruthers
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Re-Thinking the Principles of (Vocabulary) Learning and Their Applications
LanguagesMaking vocabulary stick in your memory involves dedicating attention to what needs to be learned. There are three main factors involved (focus, quantity, and quality) which can be expressed as six principles (focus, accuracy, repetition, time-on-task ...
Paul Nation
doaj +1 more source