Results 121 to 130 of about 35,153 (171)

Chromosome-level genome assembly of Schizodactylus jimo He, 2021 from China (Ensifera: Schizodactylidae). [PDF]

Sci Data
Yao B, Jiang T, Yang L, Wang J, Guan D, Xu SQ.   +5 more
europepmc   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

Uncovering the genome evolutionary dynamics of the Mediterranean endemic palm Chamaerops humilis. [PDF]

BMC Plant Biol
Labella-Ortega M, Tartaglia M, Zuzolo D, Prigioniero A, Maisto M, Ranauda MA, Fosso E, Chen H, Schicchi R, Bazan G, Cipriani G, Soltis DE, Soltis PS, Guarino C.   +13 more
europepmc   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Continuous Purification of mRNA Produced by In Vitro Transcription Using High Performance Countercurrent Membrane Purification

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Messenger ribonucleic acid (mRNA) therapeutics produced by in vitro transcription must be purified to remove residual enzymes and free nucleotides. This study examines the use of high‐performance countercurrent membrane purification (HPCMP) for the purification of mRNA therapeutics based on differences in the rate of diffusion across ...
Ziqiao Wang, Amin Javidanbardan, Ali Behboudi, Andrew L. Zydney   +3 more
wiley   +1 more source

Chromosome level genome assembly of the American sloughgrass (Beckmannia syzigachne). [PDF]

Sci Data
Tang W, Yin C, Gao H, Lu Z, Lu Y, Xu H.
europepmc   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Characteristics of the mitochondrial genome of the invasive plant Tagetes minuta (Asteraceae) on the Qinghai-Tibet Plateau and its evolutionary significance. [PDF]

BMC Genomics
Bonjor N, Zeng Z, Wang R, Dolma D, Zhang H, He J, Bacuo C, Norbu N, Jia X, Qiong, Wang J.   +10 more
europepmc   +1 more source

Breaking Barriers in Large Classes: Using Cloud Computing and Computational Biology to Implement Research‐Inspired Curricula in Biochemistry I

Biochemistry and Molecular Biology Education, EarlyView.
ABSTRACT Course‐based undergraduate research experiences (CUREs) are a high impact instructional approach but are challenging to implement in large lecture courses due to class size and content demands. We describe the evolution of a research‐inspired project in a large‐enrollment (70+ students) Biochemistry lecture course.
Christopher E. Berndsen, Kathryn E. Shenk, Alyssa Young, Sara E. Scanlan, Angelina M. Sardelli, Angela J. Kayll   +5 more
wiley   +1 more source

Oxford Nanopore Sequencing in pediatric emergency infectious diseases: from rapid diagnosis to precision medicine. [PDF]

Front Cell Infect Microbiol
Guo Y, Cheng A, Huang Y.
europepmc   +1 more source