Results 91 to 100 of about 3,177,687 (289)

Medial-Pivot Total Knee Arthroplasty with Kinematic Alignment Produces Similar Clinical Outcomes in Valgus and Varus Deformities

JBJS Open Access
Background:. Mechanical alignment total knee arthroplasty (TKA) in valgus knees requires soft tissue releases and complex techniques that are unnecessary with kinematic alignment (KA).
Emma N. Horton, BS, Lauren K. Holbrook, MS, David F. Scott, MD   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The effects of replacement schemes on car sales: the Spanish case [PDF]

This paper studies a model of car replacement designed to evaluate policies addressed to influence replacement decisions. An aggregate hazard function is computed from optimal replacement rules of heterogeneous consumers, which mimics the hump-shaped ...
Antonio R. Sampayo, Omar Licandro
core  

Effects of C, Cu and Be substitutions in superconducting MgB2

, 2001
Density functional calculations are used to investigate the effects of partial substitutional alloying of the B site in MgB2 with C and Be alone and combined with alloying of the Mg site with Cu.
A. Sharoni, B.M. Klein, D. A. Papaconstantopoulos, D. J. Singh, D. J. Singh, D. Singh, D.A. Papaconstantopoulos, D.C. Larbalestier, D.K. Finnemore, D.R. Armstrong, G.D. Gaspari, J. Kortus, J. Nagamatsu, J.H. Schon, J.M. An, J.S. Slusky, K.-P. Bohnen, L. Hedin, M. J. Mehl, N.I. Medvedeva, P.C. Canfield, R. Osborn, S.L. Bud’ko, S.L. Bud’ko, V. P. Antropov, Y. Bugoslavsky, Y. Kong   +26 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Rapid reduction in surgical time and high level of accuracy in alignment and femoral component size prediction in robotic‐assisted total knee arthroplasty with ROSA Knee System

Journal of Experimental Orthopaedics
Purpose Robotic‐assisted total knee arthroplasty (RA‐TKA) has gained popularity for its potential ability to improve surgical precision and patient outcomes, despite concerns about its long learning curve and increased operative times.
Stefano Petrillo, Giorgio Moretti, Niccolò Bordignon, Sergio Romagnoli   +3 more
doaj   +1 more source

Computer navigation has no beneficial effect on blood loss and transfusion in sequential bilateral total knee Arthroplasty

Journal of Orthopaedic Surgery, 2019
Background: Bilateral total knee arthroplasty is associated with significant blood loss. Postoperative anaemia retards patients recovery, and blood transfusion increases the risk for major complications including infection.
Anoop Jhurani, Piyush Agarwal, Mukesh Aswal, Pramod Jain, Sricharan Malepati, Ritu Sharma   +5 more
doaj   +1 more source

Peritonitis-induced peritoneal injury models for research in peritoneal dialysis review of infectious and non-infectious models

Renal Replacement Therapy, 2017
Peritonitis is an important complication of peritoneal dialysis. Several animal peritonitis models have been described, including bacterial and fungal models that are useful for studying inflammation in peritonitis. However, these models have limitations
Yasuhiko Ito, Hiroshi Kinashi, Takayuki Katsuno, Yasuhiro Suzuki, Masashi Mizuno   +4 more
doaj   +1 more source

Yang–Mills Replacement [PDF]

The Journal of Geometric Analysis, 2017
We develop an analog of harmonic replacement in the gauge theory context. The idea behind harmonic replacement dates back to Schwarz and Perron. The technique, as introduced by Jost and further developed by Colding and Minicozzi, involves taking a map $v\colon \to M$ defined on a surface $ $ and replacing its values on a small ball $B^2\subset ...
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source