Results 71 to 80 of about 1,081,239 (268)

Medial-Pivot Total Knee Arthroplasty with Kinematic Alignment Produces Similar Clinical Outcomes in Valgus and Varus Deformities

JBJS Open Access
Background:. Mechanical alignment total knee arthroplasty (TKA) in valgus knees requires soft tissue releases and complex techniques that are unnecessary with kinematic alignment (KA).
Emma N. Horton, BS, Lauren K. Holbrook, MS, David F. Scott, MD   +2 more
doaj   +1 more source

Replacing factor VIII replacement? [PDF]

Science, 2016
Medicine Hemophilia A is a bleeding disorder caused by a deficiency of factor VIII, a protein essential for blood clotting. Injection of recombinant or plasma-derived factor VIII is an effective prophylactic treatment. Factor replacement therapy has drawbacks, however, as it requires multiple injections each week and can induce antibodies that inhibit ...
openaire   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Peritonitis-induced peritoneal injury models for research in peritoneal dialysis review of infectious and non-infectious models

Renal Replacement Therapy, 2017
Peritonitis is an important complication of peritoneal dialysis. Several animal peritonitis models have been described, including bacterial and fungal models that are useful for studying inflammation in peritonitis. However, these models have limitations
Yasuhiko Ito, Hiroshi Kinashi, Takayuki Katsuno, Yasuhiro Suzuki, Masashi Mizuno   +4 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Rapid reduction in surgical time and high level of accuracy in alignment and femoral component size prediction in robotic‐assisted total knee arthroplasty with ROSA Knee System

Journal of Experimental Orthopaedics
Purpose Robotic‐assisted total knee arthroplasty (RA‐TKA) has gained popularity for its potential ability to improve surgical precision and patient outcomes, despite concerns about its long learning curve and increased operative times.
Stefano Petrillo, Giorgio Moretti, Niccolò Bordignon, Sergio Romagnoli   +3 more
doaj   +1 more source

Fluid replacement [PDF]

British Medical Bulletin, 1999
Appropriate fluid replacement is an essential component of trauma patient resuscitation. Once haemorrhage is controlled, the restoration of normovolaemia is a priority. In the presence of uncontrolled haemorrhage, aggressive fluid resuscitation may be harmful.
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Computer navigation has no beneficial effect on blood loss and transfusion in sequential bilateral total knee Arthroplasty

Journal of Orthopaedic Surgery, 2019
Background: Bilateral total knee arthroplasty is associated with significant blood loss. Postoperative anaemia retards patients recovery, and blood transfusion increases the risk for major complications including infection.
Anoop Jhurani, Piyush Agarwal, Mukesh Aswal, Pramod Jain, Sricharan Malepati, Ritu Sharma   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source