Results 91 to 100 of about 1,688,636 (315)
Journal of Monetary Economics, 1994 Abstract A prototypical vintage capital model of economic growth is developed, where the decision to replace old technologies with new ones is modeled explicitly. Technological change is investment specific. Depreciation in this environment is an economic, not a physical, concept.
Thomas F. Cooley +2 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Discrete-continuous analysis of optimal equipment replacement [PDF]
In Operations Research, the equipment replacement process is usually modeled in discrete time. The optimal replacement strategies are found from discrete (or integer) programming problems, well known for their analytic and computational complexity.
YATSENKO, Yuri, HRITONENKO, Natali
core
OSTEOPETROSIS AND ENDOPROSTHETICS - CLINICAL OBSERVATIONS
Наука и инновации в медицине, 2017 Aim - to evaluate the efficacy of treatment of secondary arthrosis of the coxofemoral joints associated with osteopetrosis using arthroplasty. Materials and methods - clinical observation of two cases of treatment of patients with autosomal dominant form
NS S Nikolaev +5 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Technological breakthroughs and asset replacement [PDF]
The authors analyze the optimal replacement of assets under continuous and discontinuous technological change. They investigate the variable lifetime of assets in an infinite-horizon replacement problem.
Yatsenko, Yuri, Hritonenko, Natali
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Hormone replacement therapy: perspectives from women, medicine and sociology [PDF]
, 1997 Developed on the boundary between medicine and sociology, this thesis develops a critique of the perspectives of these disciplines through analysis of a study of women's perspectives on hormone replacement therapy.
Griffiths, Frances Ellen +1 more
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Asset replacement for an urban railway using a modified two-cycle replacement model
, 2007 This paper considers the application of capital replacement models at Mass Transit Railway Corporation Limited (MTRCL), Hong Kong. A particular characteristic of the replacement problems considered is that costs relating to existing equipment are ...
Scarf, PA +3 more
core +1 more source
JBJS Open AccessBackground:. Mechanical alignment total knee arthroplasty (TKA) in valgus knees requires soft tissue releases and complex techniques that are unnecessary with kinematic alignment (KA).
Emma N. Horton, BS +2 more
doaj +1 more source