Results 141 to 150 of about 3,382,502 (337)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Trends and Outcomes of Off-label Use of Transcatheter Aortic Valve Replacement

, 2017
Ravi S. Hira, Sreekanth Vemulapalli, Zhuokai Li, James M. McCabe, John S. Rumsfeld, Samir Kapadia, Mahboob Alam, Hani Jneid, Creighton W. Don, Mark Reisman, Salim S. Virani, Neal S. Kleiman   +11 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Reducing edge loading and alignment outliers with image-free robotic-assisted unicompartmental knee arthroplasty: a case controlled study

Arthroplasty
Background Survivorship of medial unicompartmental knee arthroplasty (UKA) is technique-dependent. Correct femoral-tibial component positioning associates with improved survivorship.
Wai Hong Lau, Wai Kiu Thomas Liu, Kwong Yuen Chiu, Man Hong Cheung, Amy Cheung, Ping Keung Chan, Vincent Wai Kwan Chan, Henry Fu   +7 more
doaj   +1 more source

Extended Trochanteric Osteotomy Increases the Risk of Tapered Splined Stem Subsidence in Revision Total Hip Arthroplasty

JBJS Open Access
Introduction:. In the United States, tapered splined titanium stems (TSTSs) are the most frequently used femoral stem design in revision total hip arthroplasty.
Josef E. Jolissaint, MD, Samuel Rodriguez, MD, Leonardo Albertini Sanchez, BA, Travis R. Weiner, BS, Elizabeth B. Gausden, MD, MPH, Jason L. Blevins, MD, Peter Sculco, MD, Jose Rodriguez, MD, FAOA   +7 more
doaj   +1 more source

House Prices and Replacement Cost: A Micro-Level Analysis [PDF]

According to housing investment models, house prices and replacement cost should have an equilibrating relationship. Previous empirical work mainly based on aggregate-level data has found only little evidence of such a relationship.
Axel Werwatz, Rainer Schulz
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Neck fracture of the Exeter stem in 3 patients: A cause for concern?

Acta Orthopaedica, 2016
Aleksi Reito, Antti Eskelinen, Jorma Pajamäki, Timo Puolakka   +3 more
doaj   +1 more source

Postoperative Pain and Opiate Requirement is Increased Following Second-Side Surgery Among Patients Undergoing Staged Total Knee Arthroplasty

Arthroplasty Today
Background: Primary total knee arthroplasty (TKA) continues to grow exponentially, with a significant subset of patients requiring staged bilateral procedures.
Vivek P. Chadayammuri, MD, Shuvalaxmi D. Haselton, MS, Elizabeth Diaz, PA-C, Roger H. Emerson, MD   +3 more
doaj   +1 more source

Land management practices for combating desertification cause species replacement of desert lizards [PDF]

, 2006
Dror Hawlena, Amos Bouskila
openalex   +1 more source