Results 61 to 70 of about 3,177,687 (289)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Willingness to repeat discharge on day of surgery after hip and knee arthroplasty
Bone & Joint OpenAims: The limited documentation on patients’ perspectives on undergoing discharge on the day of surgery impedes its adoption as a standard of care. Hence, the aim of this study was to investigate whether patients were willing to repeat being discharged ...
Oddrún Danielsen +8 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Opioid Use Following Primary Unilateral Total Knee Arthroplasty Varies With Age
Arthroplasty TodayBackground: Reducing unused prescribed opioids following arthroplasty procedures remains a challenge. The relationship between opioid consumption and age has seldom been investigated.
Shah Fahad, MD +7 more
doaj +1 more source
Generic homonyms in the Colydiinae (Coleoptera: Zopheridae) [PDF]
, 2001 New replacement names are proposed: Megapnosaurus Ivie, Slipinski and Wegrzynowicz NEW REPLACEMENT NAME for Syntarsus Raath 1969 (Ceratosauria: Coelophysidae), not Syntarsus Fairmaire 1869 (Coleoptera: Zopheridae: Colydiinae); and Stephaniolus Ivie ...
Ivie, Michael A. +2 more
core +1 more source
Simultaneous Replacement in Normal Programs [PDF]
, 1996 The simultaneous replacement transformation operation is here defined and studied w.r.t. normal programs. We give applicability conditions able to ensure the correctness of the operation w.r.t.
Bossi, Annalisa +2 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Revista Española de Cirugía Ortopédica y Traumatología (English Edition), 2012 Elbow replacement or arthroplasty is a good therapeutic option for a large percentage of patients with significant joint destruction. However, many orthopaedic surgeons are no familiar with the surgical approaches or techniques associated with elbow replacement implants.
N, Mora-Navarro, J, Sánchez-Sotelo
openaire +2 more sources
Estimation of component redundancy in optimal age maintenance [PDF]
, 2012 The classical Optimal Age-Replacement defines the maintenance strategy based on the equipment failure consequences. For severe consequences an early equipment replacement is recommended. For minor consequences the repair after failure is proposed.
Garção, José +2 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source