Results 71 to 80 of about 3,177,687 (289)

Fracture of the insert cone of a polyethylene liner in a failed posterior-stabilized, rotating-platform total knee arthroplasty

Arthroplasty Today, 2018
Failures unique to posterior cruciate-substituting total knee prostheses rarely include polyethylene post fractures but have been described. We report a case involving a fracture of the distal insert cone of a rotating-platform (RP) polyethylene liner in
Marc R. Angerame, MD, Jason M. Jennings, MD, DPT, Douglas A. Dennis, MD   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Wnt signaling during tooth replacement in zebrafish (Danio rerio) : pitfalls and perspectives [PDF]

, 2014
The canonical (13-catenin dependent) Wnt signaling pathway has emerged as a likely candidate for regulating tooth replacement in continuously renewing dentitions.
Elderweirdt, Fien, Huysseune, Ann, Soenens, Mieke   +2 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Evaluating the effects of turf-replacement programs in Los Angeles [PDF]

, 2019
Water utilities incentivize turf replacement to promote water conservation, but the effects of such programs have received limited evaluations. In 2014, the Metropolitan Water District of Southern California (MWD) undertook an unprecedented investment to
Choi, DA, Gillespie, TW, Jia, S, Kidera, E, Nobles, N, Pataki, DE, Pincetl, S, Porse, E, Rodriguez, J   +8 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A criterion for separating process calculi [PDF]

, 2010
We introduce a new criterion, replacement freeness, to discern the relative expressiveness of process calculi. Intuitively, a calculus is strongly replacement free if replacing, within an enclosing context, a process that cannot perform any visible ...
A. Lapadula, C. Ene, C. Guidi, C. Palamidessi, C. Versari, C. Versari, D. Gorla, D. Gorla, D. Gorla, D. Sangiorgi, F. Banti, Federico Banti, Francesco Tiezzi, Frank D. Valencia, I. Phillips, I. Phillips, I. Phillips, J. Aranda, J. Baeten, J. Bengtson, J. Parrow, L. Aceto, L. Cardelli, M. Baldamus, M. Carbone, M.G. Vigliotti, P. Giambagi, R. Cleaveland, R. Cleaveland, R. Milner, R. Milner, R.J. van Glabbeek, R.M. Amadio, Rosario Pugliese, Sibylle Fröschle, U. Nestmann, U. Nestmann, U. Nestmann, Y. Fu   +38 more
core   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

OSTEOPETROSIS AND ENDOPROSTHETICS - CLINICAL OBSERVATIONS

Наука и инновации в медицине, 2017
Aim - to evaluate the efficacy of treatment of secondary arthrosis of the coxofemoral joints associated with osteopetrosis using arthroplasty. Materials and methods - clinical observation of two cases of treatment of patients with autosomal dominant form
NS S Nikolaev, LV V Borisova, SN N Didichenko, NV V Bezludnaya, IB B Bashkova, EA A Lyubimov   +5 more
doaj   +1 more source

Non-neoplastic indications and outcomes of the proximal and distal femur megaprosthesis: a critical review

Knee Surgery & Related Research, 2020
Purpose Megaprosthesis or endoprosthetic replacement of the proximal and distal femur is a well-established modality for treatment of tumors. The indications for megaprosthesis have been expanded to the treatment of some non-neoplastic conditions of the ...
Raju Vaishya, Sunil Singh Thapa, Abhishek Vaish   +2 more
doaj   +1 more source