Results 71 to 80 of about 3,310,318 (290)

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Strong Laws for Urn Models with Balanced Replacement Matrices

, 2011
We consider an urn model, whose replacement matrix has all entries nonnegative and is balanced, that is, has constant row sums. We obtain the rates of the counts of balls corresponding to each color for the strong laws to hold.
Dasgupta, Amites, Maulik, Krishanu
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Growth response of Heterobranchus longifilis fingerlings fed with varying levels of dietary freshwater mussel (Aspatharia sinuata) [PDF]

, 2005
A common bivalve: Freshwater mussel, Aspatharia sinuate was evaluated as a dietary protein supplement in the production diet for Heterobranchus longifilis fingerlings with mean body weight 8.34 plus or minus 10g reared in aquaria tanks.
Alatise, S.P., Ogundele, O., Olaosebikan, B.D.   +2 more
core  

A criterion for separating process calculi [PDF]

, 2010
We introduce a new criterion, replacement freeness, to discern the relative expressiveness of process calculi. Intuitively, a calculus is strongly replacement free if replacing, within an enclosing context, a process that cannot perform any visible ...
A. Lapadula, C. Ene, C. Guidi, C. Palamidessi, C. Versari, C. Versari, D. Gorla, D. Gorla, D. Gorla, D. Sangiorgi, F. Banti, Federico Banti, Francesco Tiezzi, Frank D. Valencia, I. Phillips, I. Phillips, I. Phillips, J. Aranda, J. Baeten, J. Bengtson, J. Parrow, L. Aceto, L. Cardelli, M. Baldamus, M. Carbone, M.G. Vigliotti, P. Giambagi, R. Cleaveland, R. Cleaveland, R. Milner, R. Milner, R.J. van Glabbeek, R.M. Amadio, Rosario Pugliese, Sibylle Fröschle, U. Nestmann, U. Nestmann, U. Nestmann, Y. Fu   +38 more
core   +4 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Impacts of Strike Replacement Bans in Canada [PDF]

In the labor relations area no issue generates as much controversy and division between labor and management as does the legislative ban on replacement workers.
Joseph Tracy, Morley Gunderson, Peter Cramton   +2 more
core  

Effects of C, Cu and Be substitutions in superconducting MgB2

, 2001
Density functional calculations are used to investigate the effects of partial substitutional alloying of the B site in MgB2 with C and Be alone and combined with alloying of the Mg site with Cu.
A. Sharoni, B.M. Klein, D. A. Papaconstantopoulos, D. J. Singh, D. J. Singh, D. Singh, D.A. Papaconstantopoulos, D.C. Larbalestier, D.K. Finnemore, D.R. Armstrong, G.D. Gaspari, J. Kortus, J. Nagamatsu, J.H. Schon, J.M. An, J.S. Slusky, K.-P. Bohnen, L. Hedin, M. J. Mehl, N.I. Medvedeva, P.C. Canfield, R. Osborn, S.L. Bud’ko, S.L. Bud’ko, V. P. Antropov, Y. Bugoslavsky, Y. Kong   +26 more
core   +1 more source