Results 71 to 80 of about 3,207,924 (350)

Modeling the initiation of others into injection drug use, using data from 2,500 injectors surveyed in Scotland during 2008-2009 [PDF]

, 2015
The prevalence of injection drug use has been of especial interest for assessment of the impact of blood-borne viruses. However, the incidence of injection drug use has been underresearched.
Aceijas, Avril Taylor, Bird, Burns, Day, De Angelis, Doherty, Esposito, Gore, Gore, Gore, Griffiths, Hay, Hickman, Hunt, Hunt, Hunt, Hutchinson, Hutchinson, Hutchinson, Kaplan, Kermode, Kimber, King, Law, Nelson, Overstall, R Development Core Team, Razali, Shah, Sharon J. Hutchinson, Sheila M. Bird, Simon R. White, Surveys, Design and Statistics Subcommittee of Home Office Scientific Advisory Committee, Sweeting, Taylor, Uusküla, Valdez   +37 more
core   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Peritonitis-induced peritoneal injury models for research in peritoneal dialysis review of infectious and non-infectious models

Renal Replacement Therapy, 2017
Peritonitis is an important complication of peritoneal dialysis. Several animal peritonitis models have been described, including bacterial and fungal models that are useful for studying inflammation in peritonitis. However, these models have limitations
Yasuhiko Ito, Hiroshi Kinashi, Takayuki Katsuno, Yasuhiro Suzuki, Masashi Mizuno   +4 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Reconstruction of the anatomy of the hip in total hip arthroplasty with two different kinds of stems

BMC Musculoskeletal Disorders, 2022
Background The reconstruction of the individual anatomy is important in total hip replacement. The aim of the study was to compare two different kinds of stems with respect to the reconstruction of the individual anatomy of the hip.
Bernd Fink, Mohamed Morgan, Philipp Schuster   +2 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

High Incidence of Recurrent Patellofemoral Crepitus in Total Knee Arthroplasty Patients Following Arthroscopic Debridement

Arthroplasty Today, 2023
Background: Patellofemoral crepitus is an unfavorable complication following total knee arthroplasty (TKA) with a posterior-stabilized (PS) implant.
Lindsay T. Kleeman-Forsthuber, MD, Marc Angerame, MD, Jason Jennings, MD, DPT, Keanna Lundy, BS, Anna Brady, BS, Douglas A. Dennis, MD   +5 more
doaj  

Fractal dimension evolution and spatial replacement dynamics of urban growth

, 2011
This paper presents a new perspective of looking at the relation between fractals and chaos by means of cities. Especially, a principle of space filling and spatial replacement is proposed to explain the fractal dimension of urban form.
Bak, Banks, Batty, Batty, Batty, Batty, Benguigui, Benguigui, Chen, Chen, Chen, Chen, Chen, De Keersmaecker, Dendrinos, Feng, Fotheringham, Frankhauser, Frankhauser, Holland, Jullien, Liu, Longley, May, Ni, Shen, Terzi, Thomas, Thomas, Thomas, Vicsek, Yanguang Chen   +31 more
core   +1 more source

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

OSTEOPETROSIS AND ENDOPROSTHETICS - CLINICAL OBSERVATIONS

Наука и инновации в медицине, 2017
Aim - to evaluate the efficacy of treatment of secondary arthrosis of the coxofemoral joints associated with osteopetrosis using arthroplasty. Materials and methods - clinical observation of two cases of treatment of patients with autosomal dominant form
NS S Nikolaev, LV V Borisova, SN N Didichenko, NV V Bezludnaya, IB B Bashkova, EA A Lyubimov   +5 more
doaj   +1 more source