FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Mortality differences in coronary patients with breast cancer treated with trimetazidine dihydrochloride: potential therapeutic implications. [PDF]
CardiooncologyCheng YT +7 more
europepmc +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Notification that new names of prokaryotes, new combinations and new taxonomic opinions have appeared in volume 75, part 11 of the <i>IJSEM</i>. [PDF]
Int J Syst Evol MicrobiolOren A, Göker M.
europepmc +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
A Markov Chain Replacement Strategy for Surrogate Identifiers: Minimizing Re-Identification Risk While Preserving Text Reuse. [PDF]
Electronics (Basel)Osborne JD +11 more
europepmc +1 more source
Niagara Frontier Transit Metro System and Transportation Supervisors Unit, International Brotherhood of Teamsters (IBT), Local 264 (2007) [PDF]
, 2007 core +1 more source
Do lifestyle factors affect clinical outcomes following total knee replacement? An integrated qualitative study exploring the perceptions and experiences of participants in the PRO Knee feasibility cohort study. [PDF]
Pilot Feasibility StudStephens G +3 more
europepmc +1 more source