Results 1 to 10 of about 694,823 (118)

Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms

Metabolites, 2021
Environmental pollution causes significant toxicity to ecosystems. Thus, acquiring a deeper understanding of the concentration of environmental pollutants in ecosystems and, clarifying their potential toxicities is of great significance.
Hyung Min Kim, Jong Seong Kang
doaj   +3 more sources

miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation

Frontiers in Endocrinology, 2021
miR-29a/b1 was reportedly involved in the regulation of the reproductive function in female mice, but the underlying molecular mechanisms are not clear.
Yang Guo, Yang Guo, Youbing Wu, Jiahao Shi, Hua Zhuang, Lei Ci, Lei Ci, Qin Huang, Zhipeng Wan, Zhipeng Wan, Hua Yang, Mengjie Zhang, Yutong Tan, Ruilin Sun, Leon Xu, Zhugang Wang, Ruling Shen, Ruling Shen, Jian Fei, Jian Fei   +19 more
doaj   +1 more source

Skin-to-blood pH shift triggers metabolome and proteome global remodelling in Staphylococcus epidermidis

Frontiers in Microbiology, 2022
Staphylococcus epidermidis is one of the most common bacteria of the human skin microbiota. Despite its role as a commensal, S. epidermidis has emerged as an opportunistic pathogen, associated with 80% of medical devices related infections.
Luis Gafeira Gonçalves, Susana Santos, Laidson Paes Gomes, Jean Armengaud, Maria Miragaia, Ana Varela Coelho   +5 more
doaj   +1 more source

Protocols for transgenesis at a safe harbor site in the Xenopus laevis genome using CRISPR-Cas9

STAR Protocols, 2023
Summary: We have established a new transgenesis protocol based on CRISPR-Cas9, “New and Easy Xenopus Transgenesis (NEXTrans),” and identified a novel safe harbor site in African clawed frogs, Xenopus laevis.
Yuki Shibata, Akinori Okumura, Makoto Mochii, Ken-ichi T. Suzuki   +3 more
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A simple and rapid protein purification method based on cell-surface display of SUMO-fused recombinant protein and Ulp1 protease

AMB Express, 2020
The development of novel methods for highly efficient protein purification remains a research focus in the biotechnology field because conventional purification approaches, including affinity purification, gel filtration, and ion-exchange chromatography,
Xiao-Feng Zhou, Chen-Lu Zhang, Xue-Ping Gao, Wei-Long Wang, Zheng-Fen He, Feng-Ying Jiang, Yi-Lin Pang, Jiang-Hui Li, Xiao-Jun Ren, Huai-Bin Zhou, Guo-Qiang Tan, Jian-Xin Lyu, Wu Wang   +12 more
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Acoustic Characterization for The Feeding Activities of Haliotis discus Hannai

Applied Sciences, 2023
In order to analyze the sound production mechanism and the acoustic characteristics of Haliotis discus hannai during feeding, this paper proposes a multi-source information fusion approach combining passive acoustics with videos.
Hongyue Lin, Yiyang Qian, Jia Chen, Xiaolong Gao, Mo Zhang, Weiwei You, Rongxin Zhang   +6 more
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A novel multimeric sCD19‐streptavidin fusion protein for functional detection and selective expansion of CD19‐targeted CAR‐T cells

Cancer Medicine, 2022
Background CARs are engineered receptors comprising an immunoglobulin single‐chain variable fragment (scFv) that identifies and binds to the target antigen, a transmembrane domain, and an intracellular T‐cell signaling domain.
Hui Lian, Jinhong Jiang, Yao Wang, Xiaoxiao Yu, Rong Zheng, Jing Long, Mengjie Zhou, Shirong Zhou, Cheng Wei, Ai Zhao, Jimin Gao   +10 more
doaj   +1 more source

HX009, a novel BsAb dual targeting PD1 x CD47, demonstrates potent anti-lymphoma activity in preclinical models

Scientific Reports, 2023
Both PD1/PD-L1 and CD47 blockades have demonstrated limited activity in most subtypes of NHL save NK/T-cell lymphoma. The hemotoxicity with anti-CD47 agents in the clinic has been speculated to account for their limitations. Herein we describe a first-in-
Hang Ke, Faming Zhang, Jingjing Wang, Lingxin Xiong, Xiaoyu An, Xiaolong Tu, Cen Chen, Yueying Wang, Binchen Mao, Sheng Guo, Cunxiang Ju, Xiangfei He, Ruilin Sun, Lei Zhang, Owen A. O’Connor, Qi-Xiang Li   +15 more
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ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus–pituitary–thyroid axis in male mice

Cell Death and Disease, 2021
Adhesion G protein-coupled receptor A1 (ADGRA1, also known as GPR123) belongs to the G protein-coupled receptors (GPCRs) family and is well conserved in the vertebrate lineage.
Xiao-Hong Zhang, Ling-Yun Tang, Xi-Yi Wang, Chun-Ling Shen, Wen-Feng Xiong, Yan Shen, Ying-Han Wan, You-Bing Wu, Yi-Cheng Wang, Hong-Xin Zhang, Shun-Yuan Lu, Jian Fei, Zhu-Gang Wang   +12 more
doaj   +1 more source

Editorial: Model organisms in toxicology. [PDF]

Front Toxicol
Aschner M, Dasmahapatra AK, Muriana A.
europepmc   +2 more sources