Results 21 to 30 of about 14,948,421 (258)

γ-Aminobutyric Acid Transporter Mutation GAT1 (S295L) Substantially Impairs Neurogenesis in Dentate Gyrus

Brain Sciences
Background: GABAergic signaling plays a crucial role in modulating neuronal proliferation, migration, and the formation of neural network connections. The termination of GABA transmission primarily occurs through the action of GABA transporter 1 (GAT1 ...
Weitong Liu, Yantian Yang, Yichen Liu, Bingyan Ni, Hua Zhuang, Kexin Chen, Jiahao Shi, Chenxin Zhu, Haoyue Wang, Jian Fei   +9 more
doaj   +1 more source

A Model of Discovery: The Role of Imaging Established and Emerging Non-mammalian Models in Neuroscience

Frontiers in Molecular Neuroscience, 2022
Rodents have been the dominant animal models in neurobiology and neurological disease research over the past 60 years. The prevalent use of rats and mice in neuroscience research has been driven by several key attributes including their organ physiology ...
Elizabeth M. Haynes, Elizabeth M. Haynes, Tyler K. Ulland, Kevin W. Eliceiri, Kevin W. Eliceiri, Kevin W. Eliceiri, Kevin W. Eliceiri   +6 more
doaj   +1 more source

Generation and characterization of a tamoxifen-inducible lineage tracing tool Cd2-P2A-CreERT2 knock-in mice

Frontiers in Immunology
IntroductionThe new targeted gene editing technologies, such as the CRISPR/Cas system, enable researchers to insert or delete genes at targeted loci efficiently.
Yang Guo, Mengyan Zhu, Zhilan Yu, Qing Li, Yanjuan Chen, Lei Ci, Ruilin Sun, Ruling Shen   +7 more
doaj   +1 more source

Escherichia coli alcohol dehydrogenase YahK is a protein that binds both iron and zinc [PDF]

PeerJ
Background Previous studies have highlighted the catalytic activity of Escherichia coli alcohol dehydrogenase YahK in the presence of coenzyme nicotinamide adenine dinucleotide (NAD) and metal zinc.
Feng Liang, Shujuan Sun, YongGuang Zhou, Tiantian Peng, Xianxian Xu, Beibei Li, Guoqiang Tan   +6 more
doaj   +2 more sources

Development of a Sensitive Escherichia coli Bioreporter Without Antibiotic Markers for Detecting Bioavailable Copper in Water Environments

Frontiers in Microbiology, 2020
The whole-cell bioreporters based on the cop-operon sensing elements have been proven specifically useful in the assessment of bioavailable copper ions in water environments.
Yilin Pang, Yilin Pang, Xiaojun Ren, Jianghui Li, Feng Liang, Xiaoyu Rao, Yang Gao, Wenhe Wu, Dong Li, Juanjuan Wang, Jianguo Zhao, Xufen Hong, Fengying Jiang, Wu Wang, Huaibin Zhou, Jianxin Lyu, Jianxin Lyu, Guoqiang Tan   +17 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Different syngeneic tumors show distinctive intrinsic tumor-immunity and mechanisms of actions (MOA) of anti-PD-1 treatment

Scientific Reports, 2022
Cancers are immunologically heterogeneous. A range of immunotherapies target abnormal tumor immunity via different mechanisms of actions (MOAs), particularly various tumor-infiltrate leukocytes (TILs).
Ying Jin, Xiaoyu An, Binchen Mao, Ruilin Sun, Rajendra Kumari, Xiaobo Chen, Yongli Shan, Mingfa Zang, Ling Xu, Jan Muntel, Kristina Beeler, Roland Bruderer, Lukas Reiter, Sheng Guo, Demin Zhou, Qi-Xiang Li, Xuesong Ouyang   +16 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

MicroRNA-3648 Is Upregulated to Suppress TCF21, Resulting in Promotion of Invasion and Metastasis of Human Bladder Cancer

Molecular Therapy: Nucleic Acids, 2019
Although microRNAs (miRNAs) are well-known for their potential in cancer, the function and mechanisms of miR-3648 have barely been explored in any type of cancer.
Wenrui Sun, Shi Li, Yuan Yu, Honglei Jin, Qipeng Xie, Xiaohui Hua, Shuai Wang, Zhongxian Tian, Huxiang Zhang, Guosong Jiang, Chuanshu Huang, Haishan Huang   +11 more
doaj   +1 more source

Cuscuta species: Model organisms for haustorium development in stem holoparasitic plants

Frontiers in Plant Science, 2022
Parasitic plants are notorious for causing serious agricultural losses in many countries. Specialized intrusive organs, haustoria, confer on parasitic plants the ability to acquire water and nutrients from their host plants.
Min-Yao Jhu, Neelima R. Sinha
doaj   +1 more source